{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T13:14:29Z","timestamp":1751548469656},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T00:00:00Z","timestamp":1473638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Optimal tacrolimus exposure in transplant recipients is not well established. The results from the Symphony study indicated that low\u2010target tacrolimus (trough concentrations 3\u20137\u2009\u00b5g\/L) in de novo standard risk renal transplant recipients should be appropriate. The aim of this study was to evaluate real\u2010life outcomes when applying a similar strategy in a clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre analysis was conducted in standard risk renal transplant recipients receiving low\u2010target tacrolimus, mycophenolate mofetil, glucocorticoids and basiliximab induction. One\u2010year estimated glomerular filtration rate (eGFR, Cockcroft\u2010Gault), one\u2010year biopsy\u2010proven acute rejection rate and graft\u2010 and patient survival up to 3 years post\u2010transplant were compared with the outcomes in the Symphony study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1 January 2009 to 31 March 2013, we included 406 patients. One year after transplantation, the mean\u2009\u00b1\u2009SD eGFR was 76.8\u2009\u00b1\u200928.3\u2009mL\/min (Symphony: 65.4\u2009\u00b1\u200927.0\u2009mL\/min, <jats:italic>P\u2009&lt;<\/jats:italic>\u20090.001). Biopsy\u2010proven acute rejections were seen in 14.5% of the patients (Symphony: 12.3%, <jats:italic>P\u2009=<\/jats:italic>\u20090.35). Kaplan\u2013Meier estimates [95% confidence interval] of three\u2010year death\u2010censored graft\u2010 and patient survival were 96.6% [94.2\u201399.0%] (Symphony: 93%) and 95.0% [92.6\u201397.3%] (Symphony: 95%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010target tacrolimus\u2010based immunosuppression is safe and effective also in a standard clinical setting in de novo standard risk renal transplant recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12738","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T15:20:29Z","timestamp":1454426429000},"page":"821-827","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low\u2010target tacrolimus in de novo standard risk renal transplant recipients: A single\u2010centre experience"],"prefix":"10.1111","volume":"21","author":[{"given":"Elisabet","family":"St\u00f8rset","sequence":"first","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\u00c5sberg","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"School of Pharmacy University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna V.","family":"Reis\u00e6ter","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hallvard","family":"Holdaas","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Skauby","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stein","family":"Bergan","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Oslo  Oslo Norway"},{"name":"Department of Pharmacology Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Midtvedt","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12579"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318198d092"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199610150-00005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199708150-00012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199704150-00013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07875-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(98)00049-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2003.00038.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067411"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03791106"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02834.x"},{"key":"e_1_2_6_13_1","article-title":"Five\u2010year outcomes after a change from a cyclosporin\u2010based to a \u201clow\u2010dose\u201d tacrolimus\u2010based primary immunosuppression regimen for incident kidney transplants\u2013the Glasgow experience","volume":"95","author":"Geddes CC","year":"2012","journal-title":"Clin. 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