{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:39:30Z","timestamp":1779100770728,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,8]],"date-time":"2017-01-08T00:00:00Z","timestamp":1483833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chinese University of Hong Kong (CUHK)","award":["6901031"],"award-info":[{"award-number":["6901031"]}]},{"name":"Chinese University of Hong Kong (CUHK)","award":["6900570"],"award-info":[{"award-number":["6900570"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>C\u2010reactive protein (CRP) is a mediator of systemic inflammation. Peritoneal dialysis (PD) is known to cause peritoneal inflammation and fibrosis. We compare the degree of peritoneal inflammation and fibrosis in wild\u2010type (WT) and CRP\u2010transgenic (Tg) mice after PD treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>WT (<jats:italic>n\u2009=<\/jats:italic>\u20097) and CRP\u2010Tg (<jats:italic>n\u2009=<\/jats:italic>\u200910) C57BL\/6\u2009J mice (all male, 10\u201312 weeks old) were injected intra\u2010peritoneally with 4.25% dextrose PD solution (3\u2009mL\/mouse) daily for 28\u2009days, followed by a 2\u2010h peritoneal equilibration test (PET). The mice were then killed. Parietal peritoneal and omental tissues were collected for the assessment of inflammation and fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 28\u2009days of PD treatment, CRP\u2010Tg mice had higher dialysate\u2010to\u2010plasma (D\/P) creatinine ratio than that of WT mice. Parietal peritoneum of the CRP\u2010Tg mice was more cellular and thicker than that of the WT mice. CRP\u2010Tg mice also had higher connective tissue growth factor (CTGF), intercellular adhesion molecule 1 (ICAM1) and tumor necrosis factor \u03b1 (TNF\u03b1) RNA expressions as well as immunohistochemical staining in the parietal peritoneum than that of the WT mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CRP\u2010Tg mice have significantly more inflammation and fibrosis than WT mice after PD treatment. Our results suggest that CRP play a role in inflammation and fibrosis induced by PD. The implication of our results to human PD therapy needs further investigations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12741","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T08:47:25Z","timestamp":1455007645000},"page":"125-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Peritoneal inflammation and fibrosis in C\u2010reactive protein transgenic mice undergoing peritoneal dialysis solution treatment"],"prefix":"10.1111","volume":"22","author":[{"given":"Peter Yam\u2010Kau","family":"Poon","sequence":"first","affiliation":[{"name":"Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Yao","family":"Lan","sequence":"additional","affiliation":[{"name":"Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie Ching\u2010Ha","family":"Kwan","sequence":"additional","affiliation":[{"name":"Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Ru","family":"Huang","sequence":"additional","affiliation":[{"name":"Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Ming","family":"Chow","sequence":"additional","affiliation":[{"name":"From Carol &amp; Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine &amp; Therapeutics Prince of Wales Hospital  Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk\u2010Chun","family":"Szeto","sequence":"additional","affiliation":[{"name":"Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong  Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip Kam\u2010Tao","family":"Li","sequence":"additional","affiliation":[{"name":"From Carol &amp; Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine &amp; Therapeutics Prince of Wales Hospital  Shatin Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/039139889702000804"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.03.038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn068"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.01.019"},{"issue":"3","key":"e_1_2_7_6_1","first-page":"237","article-title":"Systemic inflammation in dialysis patients with end\u2010stage renal disease: causes and consequences","volume":"56","author":"Yao Q","year":"2004","journal-title":"Minerva Urol. 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