{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:05:59Z","timestamp":1781809559934,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Protein\u2010energy wasting (PEW), defined as a loss of body protein mass and fuel reserves, is a powerful predictor of adverse outcomes in haemodialysis (HD) patients. Robust arguments suggest that intra\u2010dialytic exercise, combined with oral\/parenteral nutrition, enhances the effect of nutritional interventions in HD patients. This pilot randomized controlled trial investigated the feasibility and the effects of a 6\u2009month intra\u2010dialytic cycling program combined to a nutritional support on PEW, physical functioning (gait, balance, muscle strength) and quality of life (QoL) in older HD patients (mean age 69.7\u2009\u00b1\u200914.2\u2009years).Twenty\u2010one patients fulfilling diagnostic criteria of PEW were randomly assigned to Nutrition\u2010Exercise group (G<jats:sub>N\u2010Ex<\/jats:sub>, <jats:italic>n<\/jats:italic>\u2009=\u200910) or Nutrition group (G<jats:sub>N<\/jats:sub>, <jats:italic>n<\/jats:italic>\u2009=\u200911). Both groups received nutritional supplements in order to reach recommended protein and energy intake goals. In addition G<jats:sub>N\u2010Ex<\/jats:sub> completed a cycling program. No significant difference between groups was found in the number of patients having reached remission of PEW. Likewise, no change was observed in serum\u2010albumin, \u2010prealbumin, C\u2010reactive protein, body mass index, lean\u2010 and fat\u2010tissue index, or quadriceps force. Interestingly, we found positive effects of exercise on physical function and QoL for the G<jats:sub>N\u2010Ex<\/jats:sub>, as evidenced by a significant improvement in the 6\u2010min walk test (+22%), the absence of decline in balance (unlike the G<jats:sub>N<\/jats:sub>), and a noteworthy increase in QoL (+53%). Combining intra\u2010dialytic exercise and nutrition in HD patients is feasible, and well accepted, improves physical function and QoL but it appears not to have the potential to reverse PEW.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12752","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T23:40:32Z","timestamp":1455838832000},"page":"785-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Combining intra\u2010dialytic exercise and nutritional supplementation in malnourished older haemodialysis patients: Towards better quality of life and autonomy"],"prefix":"10.1111","volume":"21","author":[{"given":"Dan","family":"Hristea","sequence":"first","affiliation":[{"name":"Dialysis Unit La\u00ebnnec, ECHO Association  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Laboratory MIP (UPRES\u2010EA4334) University of Nantes  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Paris","sequence":"additional","affiliation":[{"name":"Dialysis Unit La\u00ebnnec, ECHO Association  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Lefran\u00e7ois","sequence":"additional","affiliation":[{"name":"Dialysis Unit Confluent, ECHO Association  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Collet","sequence":"additional","affiliation":[{"name":"Biometrics, CHU Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corneliu","family":"Savoiu","sequence":"additional","affiliation":[{"name":"Dialysis Unit La\u00ebnnec, ECHO Association  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Ozenne","sequence":"additional","affiliation":[{"name":"Dialysis Unit La\u00ebnnec, ECHO Association  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Coupel","sequence":"additional","affiliation":[{"name":"Dialysis Unit Confluent, ECHO Association  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Testa","sequence":"additional","affiliation":[{"name":"Dialysis Unit Confluent, ECHO Association  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Magnard","sequence":"additional","affiliation":[{"name":"Laboratory MIP (UPRES\u2010EA4334) University of Nantes  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0650-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002585"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm020"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2011.01471.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070794"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm773"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/165019702317242695"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.12.2927"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-259"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.6.1503"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369253"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.34520"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70202-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010034"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.16200"},{"key":"e_1_2_9_17_1","first-page":"845","article-title":"Lower\u2010extremity function in persons over the age of 70 as a predictor of subsequent disability","volume":"43","author":"Guralnik J","year":"1995","journal-title":"New Engl. 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