{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:52:51Z","timestamp":1782604371167,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytomegalovirus (CMV) infection is the most common infectious complication following solid organ transplantation. Ganciclovir (GCV)\u2010resistant CMV infection may be fatal, and is difficult to treat while avoiding allograft rejection. A 31\u2010year\u2010old woman received a second ABO\u2010incompatible kidney transplant, from her father. Induction therapy consisted of basiliximab and rituximab followed by maintenance immunosuppression with tacrolimus, mycophenolate mofetil, and methylprednisolone. Her CMV serostatus was D<jats:sup>+<\/jats:sup>\/R<jats:sup>\u2010<\/jats:sup> at second transplant and she received prophylactic low\u2010dose valganciclovir (VGCV). BK polyoma virus nephropathy (BKVN) developed 7\u2009months after transplant concurrent with CMV hepatitis and retinitis. VGCV was increased to a therapeutic dose combined with reduced immunosuppression with minimal methylprednisolone (2\u2009mg\/day) and everolimus (0.5\u2009mg\/day). However, pp65 antigenaemia continued to increase for 6\u2009weeks. Her CMV was defined as ganciclovir (GCV)\u2010resistant. Foscarnet was therefore administered and her CMV disease resolved within 2\u2009weeks. Kidney allograft dysfunction developed 9\u2009months after transplant, and graft biopsy showed tubulointerstitial injury with crystal deposition suggesting foscarnet nephrotoxicity, with no findings of BKVN or rejection. Kidney function recovered after cessation of foscarnet and the patient had good graft function 18\u2009months after transplant. This case demonstrates the successful use of foscarnet to treat GCV\u2010resistant CMV infection after ABO\u2010incompatible kidney transplant complicated with BKVN, without acute allograft rejection. This case further highlights the need to establish appropriate management for CMV D<jats:sup>+<\/jats:sup>\/R<jats:sup>\u2010<\/jats:sup> patients to avoid the acquisition of GCV\u2010resistant gene mutations.<\/jats:p>","DOI":"10.1111\/nep.12767","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T16:07:51Z","timestamp":1457798871000},"page":"63-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Successful treatment with foscarnet for ganciclovir\u2010resistant cytomegalovirus infection in a kidney transplant recipient: A case report"],"prefix":"10.1111","volume":"21","author":[{"given":"Daiki","family":"Iwami","sequence":"first","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hokkaido University Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Hokkaido Renal Pathology Center  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Hokkaido Renal Pathology Center  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-012-0292-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.3.576"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00009-10"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199609053351007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199141010-00009"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12349"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829df29d"},{"key":"e_1_2_5_9_1","first-page":"46","volume-title":"Diagnostic Pathology: Kidney Diseases","author":"Colvin RB","year":"2011"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000167987"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12767","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T21:31:54Z","timestamp":1695677514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,24]]},"references-count":9,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/nep.12767"],"URL":"https:\/\/doi.org\/10.1111\/nep.12767","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,24]]},"assertion":[{"value":"2016-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}