{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:18:03Z","timestamp":1780474683609,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thrombotic microangiopathy (TMA) after kidney transplantation has various aetiologies, including acute antibody\u2010mediated rejection, bacterial or viral infection and immunosuppressive drugs, particularly calcineurin inhibitors. We present the case of a 28\u2010year\u2010old woman who developed TMA 30\u2009months after the transplantation of an ABO\u2010incompatible kidney from a living unrelated donor. The patient developed a sudden onset of allograft renal dysfunction and became uremic. She was transferred to our institution from a community hospital with strongly suspected acute allograft rejection. Intensive treatments for both T\u2010 and B\u2010cell mediated acute rejection, including steroid pulse therapy, double\u2010filtration plasmapheresis, antithymocyte globulin (1.5\u2009mg\/kg\u2009\u00d7\u200914\u2009days) and rituximab (100\u2009mg), were initiated during haemodialysis. However, her renal allograft function did not improve. Histopathological analysis 8\u2009days after the treatment indicated TMA, despite the absence of apparent acute T\u2010cell\u2010 or acute antibody\u2010mediated rejection. There were no symptoms of infectious diseases, such as intestinal haemorrhagic colitis or viral infection. We concluded that the use of oral contraceptives, which had been initiated 3\u2009weeks before TMA onset for the treatment of irregular vaginal bleeding, was the aetiologic agent.<\/jats:p>","DOI":"10.1111\/nep.12769","type":"journal-article","created":{"date-parts":[[2016,3,13]],"date-time":"2016-03-13T03:41:17Z","timestamp":1457840477000},"page":"41-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Thrombotic microangiopathy caused by oral contraceptives in a kidney transplant recipient"],"prefix":"10.1111","volume":"21","author":[{"given":"Hiroyuki","family":"Shirai","sequence":"first","affiliation":[{"name":"Department of Transplant Surgery International University of Health and Welfare, Atami Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yashima","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery International University of Health and Welfare, Atami Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Tojimbara","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery International University of Health and Welfare, Atami Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuho","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Anatomy Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03156.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00051.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs279"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.07.039"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91815-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31825d1587"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.423"},{"key":"e_1_2_5_9_1","first-page":"415","article-title":"Intrarenal vascular changes in patients receiving oestrogen\u2010containing compounds\u2010a clinical, histological and angiographic study","volume":"175","author":"Boyd WN","year":"1975","journal-title":"Quart. 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