{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:01:55Z","timestamp":1781200915700,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinicopathological context of rejection after kidney transplantation was well recognized. Banff conferences greatly contributed to elucidate the pathogenesis and to establish the pathologic criteria of rejection after kidney transplantation. The most important current problem of renal transplantation is de novo donor\u2010specific antibody (DSA) production leading chronic rejection and graft loss. Microvascular inflammation is considered as a reliable pathological marker for antibody\u2010mediated rejection (AMR) in the presence of DSA. Electron microscopic study allowed us to evaluate early changes in peritubular capillaries in T\u2010lymphocyte mediated rejection and transition to antibody\u2010mediated rejection. Severe endothelial injuries with edema and activated lymphocyte invaded into subendothelial space with early multi\u2010layering of peritubular capillary basement membrane suggest T\u2010lymphocyte mediated rejection induce an unbounded chain of antibody\u2010mediated rejection. The risk factors of AMR after ABO\u2010incompatible kidney transplantation are important issues. Anti\u2010ABO blood type antibody titre of IgG excess 32\u2010fold before transplant operation is the only predictable factor for acute AMR. Characteristics of chronic active antibody\u2010mediated rejection (CAAMR) are one of the most important problems. Light microscopic findings and C4d stain of peritubular capillary and glomerular capillary are useful diagnostic criteria of CAAMR. Microvascular inflammation, double contour of glomerular capillary and thickening of peritubular capillary basement are good predictive factors of the presence of de novo DSA. C4d stain of linear glomerular capillary is a more sensitive marker for CAAMR than positive C4d of peritubular capillary. Early and sensitive diagnostic attempts of diagnosing CAAMR are pivotal to prevent chronic graft failure.<\/jats:p>","DOI":"10.1111\/nep.12777","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T06:35:48Z","timestamp":1457937348000},"page":"4-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Reviewing the pathogenesis of antibody\u2010mediated rejection and renal graft pathology after kidney transplantation"],"prefix":"10.1111","volume":"21","author":[{"given":"Kunio","family":"Morozumi","sequence":"first","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Masuko Memorial Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplant Surgery Japanese Red Cross Nagoya Daini Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplant Surgery Japanese Red Cross Nagoya Daini Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Horike","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplantation Masuko Memorial Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplant Surgery Japanese Red Cross Nagoya Daini Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Narumi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplant Surgery Japanese Red Cross Nagoya Daini Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Watarai","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Kidney Transplant Surgery Japanese Red Cross Nagoya Daini Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Renal Transplant Surgery Aichi Medical University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1476","article-title":"The Banff 97 working classification of renal allograft pathology","volume":"51","author":"Racusen LC","year":"1997","journal-title":"Kidney Int."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00072.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01688.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2008.10.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251430.11723.b6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02159.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02987.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03926.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"issue":"1","key":"e_1_2_6_11_1","first-page":"24","article-title":"Electron microscopic peritubular capillary lesions: a new criterion for chronic rejection","volume":"13","author":"Oikawa T","year":"1999","journal-title":"Clin. 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