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Changes in turnover, mineralization, mass and microarchitecture impair bone quality, compromising strength and increasing susceptibility to fractures. Fractures are more common in CKD compared with the general population and result in increased morbidity and mortality. Screening for fracture risk and management of renal osteodystrophy are hindered by the complex, and still only partially understood, pathophysiology and the inadequacy of currently available diagnostic methods. Bone densitometry and bone turnover markers, although potentially helpful, have significant limitations in patients with CKD, and the \u2018gold standard\u2019 test of bone biopsy is infrequently performed in routine clinical practice. However, recent advances in high\u2010resolution bone microarchitecture imaging may offer greater potential for quantification and assessment of bone structure and strength and, when used in conjunction with serum biomarkers, may allow non\u2010invasive testing for a diagnostic virtual bone biopsy.<\/jats:p>","DOI":"10.1111\/nep.12790","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T16:37:22Z","timestamp":1459787842000},"page":"801-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Emerging role of high\u2010resolution imaging in the detection of renal osteodystrophy"],"prefix":"10.1111","volume":"21","author":[{"given":"Ashish K","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Masterson","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G","family":"Holt","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel D","family":"Toussaint","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10901012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.547"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.279"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.3014"},{"issue":"12","key":"e_1_2_6_6_1","first-page":"1846","article-title":"Risk of fractures after renal transplantation in the United States","volume":"87","author":"Nikkel LE","year":"2009","journal-title":"Translat"},{"issue":"113","key":"e_1_2_6_7_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease \u2013 mineral and bone disorder (CKD\u2010MBD)","author":"Group, K.D.I.G.O.K.C.\u2010M.W","year":"2009","journal-title":"Kidney Int. 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