{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:40:24Z","timestamp":1766486424417},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A single centre retrospective cohort study was designed to investigate the estimated glomerular filtration rate (eGFR) in school\u2010age children born with extremely low birthweight (ELBW) and to determine risk factors predictive of decreased eGFR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared eGFR based on cystatin C (CysC\u2010eGFR) between school\u2010age children born with ELBW (ELBW group, <jats:italic>n<\/jats:italic>\u2009=\u200948; median gestational age: 26.9\u2009weeks; median birthweight: 792\u2009g) and children born at term (control group, <jats:italic>n<\/jats:italic>\u2009=\u200948). The ELBW group was then further divided into a decreased CysC\u2010eGFR subgroup (eGFR &lt;90\u2009mL\/min per 1.73 m<jats:sup>2<\/jats:sup>, <jats:italic>n<\/jats:italic>\u2009=\u200920) and a normal CysC\u2010eGFR subgroup (<jats:italic>n<\/jats:italic>\u2009=\u200928), and perinatal background factors were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ELBW group showed a significantly lower CysC\u2010eGFR compared with the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Comparison between the decreased and normal CysC\u2010eGFR subgroups in the ELBW group showed that children with lower birthweight, shorter gestational age, lower 5\u2010min Apgar score, longer length of mechanical ventilation, lower weight gain in the first 11\u2009weeks, chronic lung disease, and postnatal corticosteroid administration had significantly decreased CysC\u2010eGFR. Multivariate logistic regression showed that a lower 5\u2010min Apgar score was the only independent risk factor for decreased CysC\u2010eGFR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CysC\u2010eGFR might already be decreased at school age in children born with ELBW. Renal assessment in regular follow\u2010up examinations is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12807","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T09:23:36Z","timestamp":1462008216000},"page":"463-469","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school\u2010age children with extremely low birthweight"],"prefix":"10.1111","volume":"22","author":[{"given":"Natsumi","family":"Yamamura\u2010Miyazaki","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsusuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Santo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimi","family":"Michigami","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"},{"name":"Department of Bone and Mineral Research Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Neonatology Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Satomura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Metabolism Osaka Medical Center and Research Institute for Maternal and Child Health  Izumi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"777","article-title":"Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle","volume":"64","author":"Hinchliffe SA","year":"1991","journal-title":"Lab. 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