{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:05:59Z","timestamp":1783519559790,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Prolonged QT interval is related to changes of electrolytes in haemodialysis (HD) and is associated with all\u2010cause mortality in HD patients. It is unknown if prolonged QT interval is associated with all\u2010cause mortality in peritoneal dialysis (PD) patients as the electrolytes were relatively stable in PD. We therefore investigated the association of prolonged QT interval and all\u2010cause mortality in chronic PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The QT intervals were measured in 2003 and all patients were followed to December 2012. A prolonged QT interval was defined as a QT interval\u2009&gt;\u2009450\u2009ms. The association of prolonged QT interval with all\u2010cause and cardiac\u2010specific mortality was analyzed using Cox regression and Kaplan\u2013Meier analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 306 patients, 196 (64%) patients had prolonged QT interval. The incidence density rate was 9.7 per 100 persons\u2010years for all\u2010cause mortality and 5.6 for cardiac specific mortality in patients with prolonged QT interval. Prolonged QT interval was associated with all\u2010cause mortality with a hazard ratio (HR) of 1.59 (95% confidence interval (CI): 1.06\u20132.39, <jats:italic>P\u2009=<\/jats:italic>\u20090.03] and cardiac mortality (HR: 1.66, 95% CI: 1.00\u20132.78, <jats:italic>P\u2009=<\/jats:italic>\u20090.05) with adjustments for age, gender, diabetes, and vintage of dialysis. Longer QT interval (&gt;500\u2009ms, 450\u2013500\u2009ms, and\u2009&lt;\u2009450\u2009ms) was significantly associated with a worse overall survival (<jats:italic>P\u2009=<\/jats:italic>\u20090.03, log\u2010rank test) and cardiac mortality free survival (<jats:italic>P\u2009=<\/jats:italic>\u20090.05, log\u2010rank test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prolonged QT interval was associated with all\u2010cause and cardiac mortality in patients on peritoneal dialysis. The association is independent of patient's age and diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12808","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T15:02:52Z","timestamp":1462460572000},"page":"436-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prolonged QT interval is linked to all\u2010cause and cardiac mortality in chronic peritoneal dialysis patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Huey\u2010Liang","family":"Kuo","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, College of Medicine China Medical University  Taichung Taiwan"},{"name":"Kidney Institute and Division of Nephrology, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Lung","family":"Liu","sequence":"additional","affiliation":[{"name":"Kidney Institute and Division of Nephrology, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Chia","family":"Liang","sequence":"additional","affiliation":[{"name":"Kidney Institute and Division of Nephrology, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiz\u2010Tzung","family":"Chang","sequence":"additional","affiliation":[{"name":"Kidney Institute and Division of Nephrology, Department of Internal Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"College of Medicine China Medical University  Taichung 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