{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:01:34Z","timestamp":1778155294579,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to investigate the possible association of circulating concentrations of sclerostin with abdominal aortic calcification (AAC) and cardiovascular outcomes in patients with chronic kidney disease stage 3\u20135.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and sixty\u2010one patients with CKD3\u20135D were enrolled. The patients were divided into two groups according to the presence of AAC: an AAC group (<jats:italic>n\u2009=<\/jats:italic>\u200999) and a non\u2010AAC group (<jats:italic>n\u2009=<\/jats:italic>\u200962). The concentration of serum sclerostin was measured using an enzyme\u2010linked immunosorbent assay (ELISA). AAC was evaluated using abdominal lateral X\u2010ray examination. The follow\u2010up intervals ranged from 7 to 29\u2009months (median 16\u2009months), and cardiovascular events (CVEs) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of vascular calcification (VC) was 61.5% (99\/161). Serum sclerostin was significantly higher in an AAC group than in a non\u2010AAC group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), but the concentration in the moderate\u2010to\u2010severe AAC group was lower than in the mild AAC group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Binary logistic regression analysis revealed that high serum sclerostin, high serum calcium, diabetes, and old age were independently correlated with AAC. Patients with higher sclerostin values had a reduced risk of major cardiovascular events (log\u2010rank test, <jats:italic>P\u2009=<\/jats:italic>\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum sclerostin values are associated with the presence of AAC, but are lower when AAC is moderate to severe. Higher values are predictive of reduced short\u2010term cardiovascular events. Taken together, these results suggest that sclerostin may have a role in the development of or the response to vascular calcification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12813","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T02:56:40Z","timestamp":1462935400000},"page":"286-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Serum sclerostin values are associated with abdominal aortic calcification and predict cardiovascular events in patients with chronic kidney disease stages 3\u20135D"],"prefix":"10.1111","volume":"22","author":[{"given":"Xue\u2010Rong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology the Second Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nephrology the Second 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