{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:21:41Z","timestamp":1762917701408},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim is to describe the clinical features, treatment and outcomes in Australian adults with focal segmental glomerulosclerosis and identify predictors of disease progression and all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included all patients with biopsy confirmed focal segmental glomerulosclerosis between January 1997 and June 2014 at participating hospitals. Clinical factors, histopathological findings, biochemical markers and treatments were analysed and potential predictors of doubling serum creatinine, end stage kidney disease or death identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 98 patients were included with a median follow up of 4.3\u2009years. Thirty\u2010four (35%) patients were Aboriginal or Torres Strait Islander. Focal segmental glomerulosclerosis not\u2010otherwise\u2010specified was the most common variant. Seventeen (59%) patients initially treated with immunosuppression experienced an improvement in renal function. At the end of follow up, 43 (44%) patients had progressed to the composite outcome. Baseline tubulointerstitial scarring and lower haemoglobin predicted shorter time to doubling serum creatinine. Dual diagnosis, higher serum creatinine, lower estimated glomerular filtration rate and doubling creatinine were associated with shorter time to end stage kidney disease with remission the only protective factor. Age was the only variable associated with all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Focal segmental glomerulosclerosis holds serious implications for patients. Concomitant diabetic nephropathy, higher serum creatinine and lower estimated glomerular filtration rate at renal biopsy were associated with poorer renal prognosis. Indigenous people had a female predominance and are over\u2010represented in relation to their population size, however, were not associated with poorer prognosis. Remission was the only modifiable variable and thus should be at the forefront of patient management goals and future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12816","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T08:31:30Z","timestamp":1463041890000},"page":"520-530","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical presentation, treatment and outcome of focal segmental glomerulosclerosis in Far North Queensland Australian adults"],"prefix":"10.1111","volume":"22","author":[{"given":"Alice M","family":"Greenwood","sequence":"first","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Cairns Queensland Australia"},{"name":"Department of Renal Medicine Cairns Hospital  Cairns Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronny","family":"Gunnarsson","sequence":"additional","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Cairns Queensland Australia"},{"name":"Research and Development Unit Primary Health Care and Dental Care  Southern \u00c4lvsborgy V\u00e4stra G\u00f6taland Sweden"},{"name":"Department of Public Health and Community Medicine, Institute of Medicine, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon L","family":"Neuen","sequence":"additional","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Cairns Queensland Australia"},{"name":"The George Institute for Global Health Royal Prince Alfred Hospital  Camperdown NSW"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley","family":"Oliver","sequence":"additional","affiliation":[{"name":"Pathology Queensland Queensland Health  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella J","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Cairns Hospital  Cairns Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A","family":"Baer","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Cairns Hospital  Cairns Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1106556"},{"issue":"7","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1681\/ASN.V971333","article-title":"Primary focal segmental glomerulosclerosis","volume":"9","author":"Korbet SM","year":"1998","journal-title":"J. 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