{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:04:13Z","timestamp":1791335053608,"version":"4.3.1"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010994","name":"Indian Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010994","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Primary membranous nephropathy (PMN) accounts for only 1\u20132% of nephrotic syndrome in children. Antibodies to m\u2010type phospholipase A2 receptor (aPLA<jats:sub>2<\/jats:sub>R) is seen in 70% of adult PMN cases. The present study was undertaken to study m\u2010type phospholipase A<jats:sub>2<\/jats:sub> receptor (PLA<jats:sub>2<\/jats:sub>R) status and clinical behavior in adolescent PMN cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present prospective observational study included adolescent (10\u201319 years) onset biopsy proved PMN. Patients were followed on a monthly basis with urine protein, serum albumin and creatinine. Serum aPLA<jats:sub>2<\/jats:sub>R was done at baseline and at 6 and 12 months of starting treatment. Patients were treated as per unit's protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period a total of 18 patients were enrolled. The mean age of the cases was 16.27 \u00b1 2.39 (11\u201319) years. Seventeen (94.44%) patients presented with nephrotic syndrome. The mean proteinuria and serum albumin was 4.52 \u00b1 1.93 (2.43\u20139.20) g\/day and 2.1 \u00b1 0.6 (1.1\u20133.4) g\/dL respectively. PMN was PLA<jats:sub>2<\/jats:sub>R related in 83%. aPLA2R and enhanced staining for PLA<jats:sub>2<\/jats:sub>R in glomeruli was seen in 14 (77.78%) and 13 (72.22%), respectively. Clinical remission at the end of 6 and 12 months of therapy was seen in 11 (61.11%) and 9 (50%) subjects respectively. There was a significant association of aPLA<jats:sub>2<\/jats:sub>R to clinical remission\/ resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary membranous nephropathy in adolescent population is aPLA<jats:sub>2<\/jats:sub>R related in over three\u2010quarters of the cases and the response to therapy is seen in only half of them. aPLA<jats:sub>2<\/jats:sub>R monitoring is clinically relevant and should be incorporated in the management of adolescent onset PMN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12835","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T11:42:47Z","timestamp":1466682167000},"page":"678-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Primary membranous nephropathy in adolescence: A prospective study"],"prefix":"10.1111","volume":"22","author":[{"given":"Vinod","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani Kumar","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritambhra","family":"Nada","sequence":"additional","affiliation":[{"name":"Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Suri","sequence":"additional","affiliation":[{"name":"Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Gupta","sequence":"additional","affiliation":[{"name":"Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harbir","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivekanand","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishan","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Histopathology and Pediatrics Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)91905-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1978.23"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60731-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs439"},{"key":"e_1_2_6_6_1","article-title":"PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA\u2010DQA1 genes in primary membranous nephropathy in South Asians","author":"Ramachandran R","year":"2015","journal-title":"Nephrol Dial Transplant."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12478"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2574-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-8-11"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12569"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1005-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0246-8"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.310"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1011678"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040430"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12835","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:06:26Z","timestamp":1696273586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/nep.12835"],"URL":"https:\/\/doi.org\/10.1111\/nep.12835","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,9]]},"assertion":[{"value":"2016-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}