{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:22:40Z","timestamp":1768684960311,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,17]],"date-time":"2017-09-17T00:00:00Z","timestamp":1505606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Carbon disulphide (CS<jats:sub>2<\/jats:sub>) is widely used as an organic solvent. However, there is little information available regarding the clinical manifestations and the pathological features of kidney injury caused by CS<jats:sub>2<\/jats:sub>. The current study aimed to describe the renal manifestations of a group of patients with long\u2010term occupational exposure to CS<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients with long\u2010term exposure to CS<jats:sub>2<\/jats:sub> and visiting a single centre were enrolled, with their clinical features recorded. Renal biopsies were taken from all patients, and their pathological findings were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients came from the same chemical fibre factory. Their mean age at enrollment was 36.9\u2009\u00b1\u20092.4\u2009years, and each patient had a CS<jats:sub>2<\/jats:sub> exposure duration exceeding 10\u2009years. Eight patients (80%) presented with proteinuria and none had hematuria. Two patients (20%) had underlying hypertension and five (50%) had increased serum creatinine levels. Light microscopic examination of their renal biopsy specimens revealed diffuse mesangial cell proliferation and mesangial hyperplasia in all patients. Moreover, three patients (30%) had nodular hyperplasia, resembling the lesions of diabetic nephropathy. Variable degrees of tubular atrophy and interstitial infiltrations of lymphocytes and monocytes were observed in all patients. Similarly, lectron microscopic examination showed glomerular mesangial cell proliferation and mesangial hyperplasia. Immunopathological staining for IgA and IgG, complements or hepatitis B markers (hepatitis B surface antigen and e antigen\u2010antibody) are negative in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term occupational exposure to CS<jats:sub>2<\/jats:sub> may be associated with renal injury, although the renal pathological features are often non\u2010specific.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12853","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T20:40:09Z","timestamp":1468528809000},"page":"755-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Renal pathology in patients with occupational exposure to carbon disulphide: A case series"],"prefix":"10.1111","volume":"22","author":[{"given":"Santao","family":"Ou","sequence":"first","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linwang","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,17]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Toxicological Profile for Carbon Disulfide (Update) U.S. Department of Health and Human Services Public Health Service Agency for Toxic Substances and Disease Registry.1996: p162."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(72)90112-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408448309128255"},{"key":"e_1_2_8_5_1","first-page":"235","article-title":"Carbon disulphide poisoning in viscose rayon factories","volume":"11","author":"Vigliani EC","year":"1954","journal-title":"Br. 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