{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:32:59Z","timestamp":1793719979264,"version":"4.6.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The clinical and histological features of lupus nephritis (LN) are highly variable, depending on race and ethnicity. The Japan Renal Biopsy Registry (J\u2010RBR) is a nationwide registry of renal biopsies. Here, we report a cross\u2010sectional analysis of Japanese LN using the J\u2010RBR database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Out of 18\u2009463 patients registered in the J\u2010RBR, 331 LN patients, who received renal biopsy for the first time, were extracted and their clinical features were analyzed according to the ISN\/RPS 2003 classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the 331 LN patients was 37\u2009years (women, 81.3%). The frequencies of each of the ISN\/RPS Classes were as follows: I, 1.2%; II, 7.9%; III (\u00b1V), 25.1%; IV\u2010S (\u00b1V), 13.0%; IV\u2010G (\u00b1V), 31.1%; V, 20.8%; and VI, 0.9%. The level of proteinuria and the prevalence of nephrotic syndrome were highest for Class IV\u2010G (\u00b1V). When Classes I, II, and VI were excluded from the analysis, Class IV\u2010G (\u00b1V) was significantly associated with a lower eGFR and severer haematuria than the other classes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This nationwide study revealed that Class IV\u2010G (\u00b1V) was the most prevalent form of LN in Japan and was associated with a severe clinical renal presentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12863","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T04:53:00Z","timestamp":1469595180000},"page":"885-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical and histological features of lupus nephritis in Japan: A cross\u2010sectional analysis of the Japan Renal Biopsy Registry (J\u2010RBR)"],"prefix":"10.1111","volume":"22","author":[{"given":"Keiju","family":"Hiromura","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kayakabe","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Kidney and Vascular Pathology, Faculty of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Nephrology Kanazawa Medical University School of Medicine  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Renal Disease: Classification and Atlas of Glomerular Disease","author":"Churg J","year":"1982"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000108969.21691.5D"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011060558"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015040384"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203306lu2305xx"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006090992"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008101028"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20683"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315593166"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12840"},{"key":"e_1_2_7_12_1","first-page":"115","article-title":"Clinicopathological correlations in lupus nephritis; a single center experience","volume":"3","author":"Nasri H","year":"2014","journal-title":"J. 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