{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:20:07Z","timestamp":1767183607755},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T00:00:00Z","timestamp":1513468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Autosomal dominant polycystic kidney disease (ADPKD), a systemic disorder caused by mutation in genes encoding polycystins, has been reported to lead to metabolic derangements including new\u2010onset diabetes mellitus after kidney transplantation. We analyzed markers of insulin resistance (IR), inflammation, nutritional status and insulin\u2010like growth factor\u20101 (IGF\u20101) in end\u2010stage renal disease (ESRD) patients with ADPKD and ESRD patients with other primary kidney diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a <jats:italic>post hoc<\/jats:italic> cross\u2010sectional analysis in 254 non\u2010diabetic CKD 5 patients starting on dialysis, glucose metabolism (insulin, IGF\u20101, homeostasis model assessment of IR, HOMA\u2010IR), inflammation (high sensitivity C\u2010reactive protein, interleukin\u20106, and tumour necrosis factor), nutritional status, and bone mineral density (BMD), were assessed. Survival was recorded for median time of 28\u00a0months (IQR 15\u201348\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neither indices of IR, nor IGF\u20101, inflammatory status, nutritional status, or BMD were different in patients with ADPKD as compared to other aetiologies of ESRD. Kaplan\u2013Meier curves showed better survival among the ADPKD group versus other aetiologies, even after an exclusion of diabetic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ESRD phenotype did not differ in ADPKD versus other primary kidney diseases in terms of markers of IR, inflammation, and nutritional status. This argues against the proposition that ADPKD patients are more prone to develop metabolic derangements beyond those generally observed in advanced CKD. However, additional studies are warranted to further elucidate systemic metabolic aspects of ADPKD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12927","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T09:42:49Z","timestamp":1474537369000},"page":"31-36","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Do metabolic derangements in end\u2010stage polycystic kidney disease differ versus other primary kidney diseases?"],"prefix":"10.1111","volume":"23","author":[{"given":"Magdalena","family":"Jankowska","sequence":"first","affiliation":[{"name":"Division of Renal Medicine and Baxter Novum Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Nephrology, Transplantology and Internal Medicine Medical University of Gdansk  Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Rashid","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine and Baxter Novum Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Barany","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine and Baxter Novum Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olof","family":"Heimburger","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine and Baxter Novum Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Stenvinkel","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine and Baxter Novum Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine and Baxter Novum Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu044"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.67132.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000248759.37146.3d"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820f0877"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2016.03.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.360"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.527012"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65428-4"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2011.01507.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04140510"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00422.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.3.8119189"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1588"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02470213"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu017"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.001"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00065.x"},{"key":"e_1_2_5_21_1","first-page":"619","article-title":"Cytokine profile in autosomal dominant polycystic kidney disease","volume":"41","author":"Merta M","year":"1997","journal-title":"Biochem. 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