{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:27:58Z","timestamp":1790692078276,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Abstract<\/jats:title>\n \n Haemolytic uraemic syndrome is a rare condition with an overall incidence of one to two cases in a population of 100\u00a0000 and approximately 10% of these cases are classified as atypical.\n \n Atypical haemolytic uraemic syndrome (aHUS) is a thrombotic microangiopathy (TMA) characterized by microangiopathic haemolytic anaemia (MAHA), thrombocytopenia and acute kidney injury. aHUS can be genetic, acquired or idiopathic (negative genetic screening and no environmental triggers). We describe a case of aHUS triggered by monoclonal gammopathy of renal significance (MGRS) successfully treated with plasmapheresis and a bortezomib\u2010based chemotherapy regimen, resulting in marked improvement in renal function and other markers of haemolysis. This patient has been in remission for more than 2\u00a0years currently.\n <\/jats:p>","DOI":"10.1111\/nep.12934","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T23:56:29Z","timestamp":1486511789000},"page":"15-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Monoclonal gammopathy of renal significance triggering atypical haemolytic uraemic syndrome"],"prefix":"10.1111","volume":"22","author":[{"given":"Usman","family":"Mahmood","sequence":"first","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Isbel","sequence":"additional","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mollee","sequence":"additional","affiliation":[{"name":"Department of Haematology Princess Alexandra Hospital Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Mallett","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women's Hospital Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridevi","family":"Govindarajulu","sequence":"additional","affiliation":[{"name":"Toowoomba Base Hospital Toowoomba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902814"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21256"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050453"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcv082"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-445304"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000201"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.370"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009010110"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.195"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2210-0"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860229809045182"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000155"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr422"},{"issue":"8","key":"e_1_2_4_15_1","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.4049\/jimmunol.163.8.4590","article-title":"Nephritogenic lambda light chain dimer: a unique human miniautoantibody against complement factor H","volume":"163","author":"Jokiranta TS","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09710913"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:13:53Z","timestamp":1695982433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":15,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/nep.12934"],"URL":"https:\/\/doi.org\/10.1111\/nep.12934","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"2017-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}