{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:07:52Z","timestamp":1787782072799,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify risk factors for acute kidney injury following major orthopaedic surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all patients undergoing major orthopaedic surgery at University Hospital Geelong between 2008 and 2014 in the study. Out of 2188 surgeries audited, we identified cases of acute kidney injury using the RIFLE criteria and matched those to controls 2:1 for age, sex, procedure and chronic kidney disease stage. We reviewed their records for risk factors of postoperative acute kidney injury, including medications such as gentamicin, diuretics, non\u2010steroidal anti\u2010inflammatory drugs and angiotensin\u2010converting enzyme inhibitor or angiotensin receptor blocker use. We reviewed the patients' history of cardiovascular disease, chronic liver disease, hypertension and diabetes mellitus along with presence of sepsis and obesity. Associations of hypothetical risk factors were estimated using conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 164 cases of AKI in an elderly cohort (median age\u00a0=\u00a073\u00a0years). Controlling for baseline comorbidities, both diuretic and angiotensin\u2010converting enzyme inhibitor or angiotensin receptor blocker use were found to be associated with a twofold risk of acute kidney injury (diuretic \u2013 OR 2.06 95% CI:1.30\u20133.26, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005, angiotensin\u2010converting enzyme inhibitor or angiotensin receptor blocker use OR 2.09 95% CI:1.31\u20133.32, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005). A dose\u2010effect model accounting for perioperative nonsteroidal anti\u2010inflammatory drug administration demonstrated a linear relationship between the number of times these drugs were given and postoperative acute kidney injury risk (OR 1.35 95% CI:1.05\u20131.73, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified perioperative diuretics, non\u2010steroidal anti\u2010inflammatory drugs and angiotensin\u2010converting enzyme inhibitor or angiotensin receptor blocker to be significantly associated with postoperative AKI. Further prospective studies are required to confirm this.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12942","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T18:38:27Z","timestamp":1476297507000},"page":"126-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Acute kidney injury post\u2010major orthopaedic surgery: A single\u2010Centre case\u2013control study"],"prefix":"10.1111","volume":"23","author":[{"given":"Tracey","family":"Ying","sequence":"first","affiliation":[{"name":"Department of Renal Medicine University Hospital Geelong  Geelong Victoria Australia"},{"name":"Level 6 Renal Department Royal Prince Alfred Hospital  Missenden Road Camperdown 2050 NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine University Hospital Geelong  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lane","sequence":"additional","affiliation":[{"name":"Barwon Health Biostatistics Unit University Hospital Geelong  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Somerville","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine University Hospital Geelong  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.07.018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.11.034"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2151458512473827"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2009.07.009"},{"issue":"1","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1471-2369-13-101","article-title":"Analysis of kidney dysfunction in orthopaedic patients","volume":"13","author":"Kateros K","year":"2012","journal-title":"BMC Nephrol."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfu108"},{"issue":"3","key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"e16713","DOI":"10.5812\/ijem.16713","article-title":"Predictors of acute kidney injury in geriatric patients undergoing total knee replacement surgery","volume":"12","author":"Sehgal V","year":"2014","journal-title":"Int J Endocrinol Metab."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.06012.x"},{"issue":"3","key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.arth.2010.01.021","article-title":"Renal impairment following total joint arthroplasty: who is at risk?","volume":"25","author":"Jafari S","year":"2010","journal-title":"J. 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