{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:33:44Z","timestamp":1778934824935,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T00:00:00Z","timestamp":1513468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the detailed associations of albuminuria among a contemporary cohort of Aboriginal and Torres Strait Islander people to inform strategies for chronic kidney disease prevention and management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional analysis of Indigenous participants of the eGFR Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measures<\/jats:title><jats:p>Clinical, biochemical and anthropometric measures were collected (including body\u2010circumferences, blood pressure (BP); triglycerides, HbA1c, liver function tests, creatinine; urine\u2010 microscopic\u2010haem, albumin: creatinine ratio (ACR), prescriptions\u2010 angiotensin converting enzyme inhibitor or angiotensin receptor II antagonist (ACEI\/ARB). Albuminuria and diabetes were defined by an ACR&gt;3.0 mg\/mmol, and HbA1c\u226548 mmol\/mol or prior history respectively. Waist: hip ratio (WHR), and estimated glomerular filtration rate (eGFR) were calculated. ACR was non\u2010normally distributed; a logarithmic transformation was applied (in base 2), with each unit increase in log2\u2010albuminuria representing a doubling of ACR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>591 participants were assessed (71% Aboriginal, 61.6% female, mean age 45.1 years, BMI 30.2 kg\/m<jats:sup>2<\/jats:sup>, WHR 0.94, eGFR 99.2 ml\/min\/1.73m<jats:sup>2<\/jats:sup>). The overall prevalence of albuminuria, diabetes, microscopic\u2010haem and ACEI\/ARB use was 41.5%, 41.5%, 17.8% and 34.7% respectively; 69.3% of adults with albuminuria and diabetes received an ACEI\/ARB. Using multivariable linear regression modelling, the potentially modifiable factors independently associated with log2\u2010albuminuria were microscopic\u2010haem, diabetes, WHR, systolic BP, alkaline phosphatase (all positive) and eGFR (inverse).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Albuminuria is associated with diabetes, central obesity and haematuria. High ACEI\/ARB prescribing for adults with diabetes and albuminuria was observed. Further understanding of the links between fat deposition, haematuria and albuminuria is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12956","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T04:03:09Z","timestamp":1478491389000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cross\u2010sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults: the eGFR Study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-4156","authenticated-orcid":false,"given":"JT","family":"Hughes","sequence":"first","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"},{"name":"Department of Medicine Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LJ","family":"Maple\u2010Brown","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"},{"name":"Department of Medicine Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Thomas","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PD","family":"Lawton","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sinha","sequence":"additional","affiliation":[{"name":"Cairns Base Hospital and Diabetes Centre  Cairns Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Cass","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Barzi","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GRD","family":"Jones","sequence":"additional","affiliation":[{"name":"SydPath St Vincent's Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Jerums","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne"},{"name":"Austin Health  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RJ","family":"MacIsaac","sequence":"additional","affiliation":[{"name":"University of Melbourne  Melbourne"},{"name":"Department of Endocrinology and Diabetes St Vincent's Hospital  Melbourne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"O'Dea","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research  Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WE","family":"Hoy","sequence":"additional","affiliation":[{"name":"Centre for Chronic Disease The University of Queensland  Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.9.1181"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.483"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.6.659"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01858.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12052"},{"key":"e_1_2_7_7_1","first-page":"282","volume-title":"CARPA Standard Treatment Manual","author":"CARPA","year":"2014"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-346"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0166-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00793.x"},{"key":"e_1_2_7_11_1","unstructured":"Australian Institute of Health and Welfare2011.The health and welfare of Australia's Aboriginal and Torres Strait Islander people an overview 2011. 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