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Although the explicit mechanism of LN remains to be fully elucidated, there is increasing evidence to support the notion that tumour necrosis factor\u2010related weak inducer of apoptosis (TWEAK), acting via its sole receptor, fibroblast growth factor\u2010inducible 14 (Fn14), plays a pivotal role in such pathologic process. TWEAK\/Fn14 interactions occur prominently in kidneys of LN, inducing inflammatory responses, angiogenesis, mesangial proliferation, filtration barrier injuries, renal fibrosis, etc. This review will specify the important roles of TWEAK\/Fn14 pathway in the pathogenesis of LN with experimental data from cellular and animal models. Additionally, the raised levels of urinary and serum soluble TWEAK correlate with renal disease activity in patients with LN. The neutralizing antibodies targeting TWEAK or other approaches inhibiting TWEAK\/Fn14 signals can attenuate renal damage in the murine lupus models. Therefore, to focus on TWEAK\/Fn14 signalling may be promising in both clinical evaluation and the treatment of patients with LN.<\/jats:p>","DOI":"10.1111\/nep.12957","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T09:06:36Z","timestamp":1477559196000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Roles of tumour necrosis factor\u2010related weak inducer of apoptosis\/fibroblast growth factor\u2010inducible 14 pathway in lupus nephritis"],"prefix":"10.1111","volume":"22","author":[{"given":"Jingyun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital, School of Medicine Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Wei","sequence":"additional","affiliation":[{"name":"Core Research Laboratory, The Second Affiliated Hospital, School of Medicine Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Affiliated Hospital, School of Medicine Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.06.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31827f4ee3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000794"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.159"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0308165"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2488"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.05.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-011-0420-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01054.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6612-4_32"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.09.022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001866"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32401"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903555"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.08.008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030233"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2011.01449.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3913"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.124"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2038"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033609"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.005"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.12.001"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft342"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.475"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4250"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7949"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00766.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000062883.93715.37"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1889"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00447"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.203745"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.169"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.11.017"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8986451"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-100"},{"key":"e_1_2_10_38_1","first-page":"1744","article-title":"TNF\u2010related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras\u2010dependent proliferation of cultured renal fibroblast","volume":"2013","author":"Ucero AC","year":"1832","journal-title":"Biochim. 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