{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:33:31Z","timestamp":1792262011758,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study is to provide a robust estimate of mortality risk in acute coronary syndrome (ACS)\u2010associated acute kidney injury (AKI) to inform clinical practice and policy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A meta\u2010analysis of cohort studies evaluating outcomes of ACS and which reported AKI and AKI\u2010associated mortality. Studies were excluded if they incorporated patients not admitted through the emergency department (i.e. for elective procedures), were limited to cardiogenic shock or cardiac arrest, or relied on registry data for outcomes without further adjudication. The predictor was ACS\u2010associated AKI and outcomes early (30\u00a0day or in\u2010hospital) mortality and late\u2010mortality (post\u2010hospital discharge).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six studies with 37 unique cohorts comprising 100\u00a0476 patients were included. The pooled rate of ACS\u2010associated AKI was 15.8%. In 32 cohorts reporting early mortality, the crude early mortality rate was 15.0% amongst those with AKI compared with 2.0% amongst those without AKI. The pooled estimate of the relative risk of AKI\u2010associated early mortality was 4.1 (95% confidence interval: 3.3 to 5.0) with high heterogeneity between studies (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u00a0=\u00a084% (61% to 88%)). When heterogeneity was accounted for mathematically using credibility ceilings, the risk of mortality was lower, but still clinically significant (3.1 (2.6 to 3.6)). In 19 cohorts reporting late mortality (1 to 10\u00a0years), the relative risk of AKI\u2010associated mortality was 2.6 (2.0 to 3.3) with moderate heterogeneity (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u00a0=\u00a065\u00a0% [35% to 88%]). Following application of credibility ceiling relative risk estimate dropped to 2.2 (1.9 to 2.6).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute coronary syndrome\u2010associated AKI is associated with more than a three\u2010fold increase in early mortality and more than two\u2010fold in long\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.12984","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T03:17:29Z","timestamp":1482117449000},"page":"237-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Acute Kidney Injury and mortality prognosis in Acute Coronary Syndrome patients: A meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-0344","authenticated-orcid":false,"given":"John W","family":"Pickering","sequence":"first","affiliation":[{"name":"Department of Medicine University of Otago Christchurch  Christchurch New Zealand"},{"name":"Emergency Department Christchurch hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella R H","family":"Blunt","sequence":"additional","affiliation":[{"name":"Emergency Department Christchurch hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-5227","authenticated-orcid":false,"given":"Martin P","family":"Than","sequence":"additional","affiliation":[{"name":"Emergency Department Christchurch hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.974493"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-1861-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.350"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.09.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.19.1690"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112220"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2008.05.014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d549"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040297"},{"issue":"1","key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijcard.2014.03.146","article-title":"Association of contrast\u2010induced acute kidney injury with long\u2010term cardiovascular events in acute coronary syndrome patients with chronic kidney disease undergoing emergent percutaneous coronary intervention","volume":"174","author":"Watabe H","year":"2014","journal-title":"Int. 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