{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:31:50Z","timestamp":1758817910188},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009665","name":"Vehicle Racing Commemorative Foundation","doi-asserted-by":"publisher","award":["The research grant from Vehicle Racing Commemorati"],"award-info":[{"award-number":["The research grant from Vehicle Racing Commemorati"]}],"id":[{"id":"10.13039\/100009665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004031","name":"Jichi Medical University","doi-asserted-by":"publisher","award":["JMU Graduate Student Research Award"],"award-info":[{"award-number":["JMU Graduate Student Research Award"]}],"id":[{"id":"10.13039\/501100004031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Calciprotein particles (CPPs), colloidal protein\u2010mineral nanoparticles composed of solid\u2010phase calcium phosphate and serum protein fetuin\u2010A found in blood, are emerging as a novel component of chronic kidney disease\u2010mineral and bone disorder (CKD\u2010MBD). The relationship of CPPs with factors known to underlie the CKD\u2010MBD pathophysiology is not well known.The aim of this study is to examine daily variations in CPPs as well as their association with mineral metabolism parameters in normal individuals and early\u2010stage CKD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty subjects (10 healthy adults, 10 diabetic patients) were enrolled. Serum CPP Fetuin\u2010A was measured and analyzed in relation to clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estimated glomerular filtration rates (eGFR) were 103\u00a0\u00b1\u00a011 and 75\u00a0\u00b1\u00a024\u00a0mL\/min per 1.73 m<jats:sup>2<\/jats:sup> in healthy adults and diabetic patients, respectively. Serum CPP Fetuin\u2010A (g\/L) were elevated at postprandial 2\u00a0h in diabetic patients. Furthermore, serum CPP Fetuin\u2010A were inversely correlated with eGFR and serum 1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> and magnesium levels and were positively correlated with serum fibroblast growth factor\u201023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings indicated that serum CPP Fetuin\u2010A were affected by food intake and may contribute to the pathophysiology of mineral metabolism in subjects with normal and moderately impaired renal function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12994","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T05:02:43Z","timestamp":1483506163000},"page":"226-230","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Daily variability in serum levels of calciprotein particles and their association with mineral metabolism parameters: A cross\u2010sectional pilot study"],"prefix":"10.1111","volume":"23","author":[{"given":"Hodaka","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kuro\u2010o","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine Jichi Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San\u2010e","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism International University of Health and Welfare Hospital  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Funazaki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuyo","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kakei","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology and Metabolism Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095676.90936.80"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.553198"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009090944"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr609"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210868200"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709938200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17202"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/kisup.2013.88","article-title":"A phosphate\u2010centric paradigm for pathophysiology and therapy of chronic kidney disease","volume":"3","author":"Kuro OM","year":"2013","journal-title":"Kidney Int. 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