{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:35:11Z","timestamp":1774866911606,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Despite its importance in bone and cardiovascular disease in subjects with kidney disease, there are no data on fibroblast growth factor 23 (FGF23) perturbations in nephrotic syndrome. We evaluated FGF23 and markers of mineral bone metabolism in subjects with untreated NS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, we measured circulating levels of FGF23, 25\u2010hydroxy vitamin D [25(OH)D], 1,25 di\u2010hydroxy vitamin D [1,25(OH)<jats:sub>2<\/jats:sub>D], serum albumin, serum calcium, phosphorus, creatinine and intact parathyroid hormone (iPTH) in 101 patients with adults onset NS and 40 healthy controls. We examined the correlation between FGF23 and markers of mineral bone metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to healthy controls, subjects with NS showed reduced levels of 25(OH)D (21.76\u00a0\u00b1\u00a010.18 vs 35.74\u00a0\u00b1\u00a040.27\u00a0nmol\/L, <jats:italic>P\u00a0=<\/jats:italic>\u00a00.001), 1,25(OH)<jats:sub>2<\/jats:sub>D (median; 37.80 vs 73.13\u00a0pmol\/L, <jats:italic>P\u00a0=<\/jats:italic>\u00a00.0001) and FGF23 (37.81\u00a0\u00b1\u00a020.42 vs 48.20\u00a0\u00b1\u00a011.60\u00a0pg\/mL, <jats:italic>P\u00a0=<\/jats:italic>\u00a00.004) levels. Serum phosphorus levels were marginally, but significantly higher in subjects with nephrotic syndrome compared to healthy controls (<jats:italic>P\u00a0=<\/jats:italic>\u00a00.004). Serum iPTH levels were significantly higher in subjects with NS compared to healthy controls (52.24\u00a0\u00b1\u00a039.58 vs 37.90\u00a0\u00b1\u00a014.60\u00a0pg\/mL, <jats:italic>P\u00a0=<\/jats:italic>\u00a00.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that FGF23 is reduced in subjects with NS compared to healthy controls. The reduced levels of Vitamin D, and urinary losses may contribute to lower levels of FGF23 in NS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13001","type":"journal-article","created":{"date-parts":[[2017,1,14]],"date-time":"2017-01-14T12:57:34Z","timestamp":1484398654000},"page":"362-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fibroblast growth factor 23 in untreated nephrotic syndrome"],"prefix":"10.1111","volume":"23","author":[{"given":"Ashok Kumar","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Nephrology  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Nephrology  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nephrology  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishan Lal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Nephrology  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivekanand","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Nephrology  Chandigarh India"},{"name":"George Institute for Global Health, 219\u2010221 Splendor Forum  New Delhi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"AggarwalA YadavAK RamachandranR et al.Bioavailable vitamin D levels are reduced and correlate with bone mineral density and markers of mineral metabolism in adults with nephrotic syndrome. Nephrology (Carlton). 2016; 21: 483\u20139.","DOI":"10.1111\/nep.12638"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000172717.49476.80"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.196"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.826"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp191"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010080894"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu097"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2547-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.05.024"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-20"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-147"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.13001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T20:07:21Z","timestamp":1695672441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/nep.13001"],"URL":"https:\/\/doi.org\/10.1111\/nep.13001","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]},"assertion":[{"value":"2016-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}