{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T20:42:29Z","timestamp":1780692149755,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone turnover markers assist in fracture risk prediction, management and monitoring of osteoporosis in patients without chronic kidney disease (CKD). The use in CKD\u2013mineral bone disorder (MBD) has been limited as many of these markers and breakdown products are renally excreted, including the most commonly used and well standardized procollagen type I N propeptide and C\u2010terminal cross\u2010linking telopeptide of type I collagen. Of the markers unaffected by renal function, bone specific alkaline phosphatase is associated with mortality and fracture rate in CKD subjects and is now available on several automated analysers. When used in combination with PTH, bone specific alkaline phosphatase as a bone formation marker correlated well with bone biopsy histomorphometry in predicting adynamic bone disease. Tartrate\u2010resistant acid phosphatase 5b is a resorption marker that is under development for automation.<\/jats:p><jats:p>Both high and low bone turnover in CKD\u2010MBD patients are associated with increased fracture and mortality risk. Bone biopsy as the gold standard to differentiate between adynamic bone disease and osteitis fibrosa is limited by availability and cost. Appropriate use of bone turnover markers is vital in the decision to commence anti\u2010resorptive agents, and to monitor efficacy in order to avoid over suppression of bone turnover, which may lead to stress fractures. Further efforts are required to develop markers unaffected by renal function with standardized cut\u2010off values and fracture as well as vascular calcification end\u2010points.<\/jats:p>","DOI":"10.1111\/nep.13014","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T05:40:22Z","timestamp":1492753222000},"page":"11-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The use of bone turnover markers in chronic kidney disease\u2010mineral and bone disorders"],"prefix":"10.1111","volume":"22","author":[{"given":"Cherie","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Pathology Royal Melbourne Hospital"},{"name":"Department of Endocrinology, Department of Pathology Austin Hospital"},{"name":"University of Melbourne The Royal Melbourne Hospital, Parkville  Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9842-y"},{"key":"e_1_2_5_3_1","first-page":"1127","article-title":"Association of bone turnover markers and arterial stiffness in pre\u2010dialysis chronic kidney disease (CKD)","volume":"48","author":"Manghat P","year":"2011","journal-title":"BoSne"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.602"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.07.016"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1681\/ASN.V73506","article-title":"Plasma total versus bone alkaline phosphatase as markers of bone turnover in hemodialysis patients","volume":"7","author":"Urena P","year":"1996","journal-title":"J. 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