{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T15:17:19Z","timestamp":1771600639700,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study is to determine whether the apparent benefit of revascularization of renal artery stenosis for \u2018flash\u2019 pulmonary oedema extends to heart failure patients without a history of prior acute pulmonary oedema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study of patients with renal artery stenosis and heart failure at a single centre between 1 January 1995 and 31 December 2010. Patients were divided into those with and without previous acute pulmonary oedema\/decompensation. Survival analysis compared revascularization <jats:italic>versus<\/jats:italic> medical therapy in each group using Cox regression adjusted for age, estimated glomerular filtration rate, blood pressure and co\u2010morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 152 patients: 59% male, 36% diabetic, age 70 \u00b1 9 years, estimated glomerular filtration rate 29 \u00b1 17 mL\/min per 1.73 m<jats:sup>2<\/jats:sup>; 52 had experienced previous acute pulmonary oedema (34%), whereas 100 had no previous acute pulmonary oedema (66%). The revascularization rate was 31% in both groups.<\/jats:p><jats:p>For heart failure without previous acute pulmonary oedema, the hazard ratio for death after revascularization compared with medical therapy was 0.76 (0.58\u20130.99, <jats:italic>P<\/jats:italic> = 0.04). In heart failure with previous acute pulmonary enema, the hazard ratio was 0.73 (0.44\u20131.21, <jats:italic>P<\/jats:italic> = 0.22).<\/jats:p><jats:p>For those without previous acute pulmonary oedema, the hazard ratio for heart failure hospitalization after revascularization compared with medical therapy was 1.00 (0.17\u20136.05, <jats:italic>P<\/jats:italic> = 1.00). In those with previous acute pulmonary oedema, it was 0.51 (0.08\u20133.30, <jats:italic>P<\/jats:italic> = 0.48).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The benefit of revascularization in heart failure may extend beyond the current indication of acute pulmonary oedema. However, findings derive from an observational study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13038","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T15:56:40Z","timestamp":1488211000000},"page":"411-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Revascularization of atherosclerotic renal artery stenosis for chronic heart failure <i>versus<\/i> acute pulmonary oedema"],"prefix":"10.1111","volume":"23","author":[{"given":"Darren","family":"Green","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences University of Manchester, Manchester Academic Health Sciences Centre  Manchester UK"},{"name":"Vascular Research Group Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre  Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Vascular Research Group Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre  Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantina","family":"Chrysochou","sequence":"additional","affiliation":[{"name":"Vascular Research Group Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre  Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A","family":"Kalra","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences University of Manchester, Manchester Academic Health Sciences Centre  Manchester UK"},{"name":"Vascular Research Group Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre  Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_6_3_1","unstructured":"American Heart Association.Heart disease and stroke statistics \u2013 2013 Update. 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