{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:47:48Z","timestamp":1784314068300,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the molecular mechanism mitigating progress of chronic nephropathy by mesenchymal stem cells (MSCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats were divided into normal control (Normal), adriamycin (ADR)+vehicle (CON), and ADR+MSC (MSC) groups. Nephropathy was induced by ADR (4 mg\/kg) and MSCs (2 \u00d7 10<jats:sup>6<\/jats:sup>) were injected. Rats were euthanized 1 or 6 weeks after ADR injection. NF\u2010kB, MAPKs, inflammation, oxidative stress, profibrotic molecules, and nephrin expression were evaluated. Electron and light microscopy were used for structural analysis. MSCs were co\u2010cultured with renal tubular epithelial cells or splenocytes to evaluate relation with oxidative stress and inflammatory molecules<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adriamycin treatment upregulated inflammation, oxidative stress, and profibrotic molecules; this was mitigated by MSCs. Glomerulosclerosis and interstitial fibrosis were observed in ADR\u2010treated groups, and were more prominent in the CON group than in the MSC group. Fusion of foot processes and loss of slit diaphragms were also more prominent in the CON group than in the MSC group. In vitro, MSCs reduced oxidative stress related molecules, inflammatory cytokines, and NF\u2010kB transcription. MSC\u2010 or ADR\u2010induced regulation of NF\u2010kB transcriptional activity was confirmed by a luciferase reporter assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mesenchymal stem cells attenuate ADR\u2010induced nephropathy by diminishing oxidative stress and inflammation via downregulation of NF\u2010kB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13047","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T15:04:09Z","timestamp":1490195049000},"page":"483-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Mesenchymal stem cells attenuate adriamycin\u2010induced nephropathy by diminishing oxidative stress and inflammation via downregulation of the NF\u2010kB"],"prefix":"10.1111","volume":"23","author":[{"given":"In\u2010Hwan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Anatomy Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong\u2010Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anatomy Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eon\u2010Gi","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Anatomy Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Chul","family":"Bae","sequence":"additional","affiliation":[{"name":"Pediatrics Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anatomy Kyungpook National University School of Dentistry  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.602"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020140"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05487.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/414813a"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)31020-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/394917"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft538"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602012000300010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn659"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/124730"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.06.015"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01383.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.05.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/937623"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368908787236567"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00075.2008"},{"issue":"3","key":"e_1_2_7_18_1","first-page":"325","article-title":"Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial\u2010like cells","volume":"22","author":"Qian H","year":"2008","journal-title":"Int. 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