{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:57Z","timestamp":1740126357091,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to determine whether peritoneal membrane transport status (MTS) is associated with peritonitis or poor peritoneal dialysis\u2010related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study analysed data of incident adult patients on peritoneal dialysis in Western Sydney between 1 October 2003 and 31 December 2012. Only patients who underwent peritoneal equilibration and adequacy tests within 6 months of commencement were included. Kaplan\u2013Meier survival curves for time until first peritonitis and time until composite endpoint of peritonitis, death or technique failure, censored for transplant, were constructed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 397 patients, mean age 58.8(+\/\u22122SD29) years, body mass index (BMI) 26.6(+\/\u22125) kg\/m<jats:sup>2<\/jats:sup> and serum albumin 35.4(+\/\u22125) g\/L were included. About 59.2% had high\/high\u2010average peritoneal MTS; 45.8% were past and current smokers; 51.9% developed at least one episode of peritonitis; 7.6% changed to haemodialysis; 6.3% underwent transplantation; 8.8% died; and 25.4% remained free of the aforementioned events over a mean follow\u2010up period of 22.5 months (range 0\u2013115 months). Peritoneal MTS was not associated with time to first peritonitis (<jats:italic>p<\/jats:italic> = 0.67) or composite endpoint of peritonitis, death or technique failure (<jats:italic>p<\/jats:italic> = 0.12). Smoking and hypoalbuminaemia independently predicted time to first peritonitis. Past and current smokers had a hazard ratio of 1.38 (95% CI 1.03\u20131.86) for shorter time to first peritonitis, significant after adjustment for serum albumin (<jats:italic>p<\/jats:italic> = 0.033). Serum albumin &lt;32 g\/L had a hazard ratio of 1.74 (95% CI 1.13\u20132.67) for shorter time to first peritonitis, significant after adjusting for smoking (<jats:italic>p<\/jats:italic> = 0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Smoking and hypoalbuminaemia, but not MTS, were associated with shorter time to first peritonitis and composite endpoint of peritonitis, death and technique failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13063","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T17:36:40Z","timestamp":1493055400000},"page":"633-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Membrane transport status does not predict peritonitis risk in patients on peritoneal dialysis"],"prefix":"10.1111","volume":"23","author":[{"given":"Sarah","family":"So","sequence":"first","affiliation":[{"name":"Department of Renal Medicine Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney Medical School  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laraine","family":"Aw","sequence":"additional","affiliation":[{"name":"Peritoneal Dialysis Unit, Regional Dialysis Centre Blacktown Hospital  Blacktown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Sud","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney Medical School  Sydney New South Wales Australia"},{"name":"Peritoneal Dialysis Unit, Regional Dialysis Centre Blacktown Hospital  Blacktown New South Wales Australia"},{"name":"Department of Renal Medicine Nepean Hospital  Kingswood New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-3696","authenticated-orcid":false,"given":"Vincent W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney Medical School  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437286"},{"issue":"2","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1177\/089686080902902S11","article-title":"Clinical advantages of peritoneal dialysis","volume":"29","author":"Tokgoz B","year":"2009","journal-title":"Perit. Dial. Int."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016010112"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"S91","article-title":"Impact of peritoneal membrane function on long term clinical outcome in peritoneal dialysis patients","volume":"19","author":"Davies SJ","year":"1998","journal-title":"Perit. Dial. Int."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00756.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1681\/ASN.V971285","article-title":"Increased peritoneal membrane transport is associated with decreased patient and technique survival for continuous peritoneal dialysis patients","volume":"9","author":"Churchill DN","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030194"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050566"},{"issue":"9","key":"e_1_2_7_10_1","first-page":"531","article-title":"Risk factors for peritonitis related to peritoneal dialysis","volume":"114","author":"Karagulle IV","year":"2013","journal-title":"Bratisl. Lek. Listy"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/483250"},{"issue":"178","key":"e_1_2_7_12_1","first-page":"104","article-title":"Peritonitis in continuous ambulatory peritoneal dialysis","volume":"49","author":"Sharma SJ","year":"2010","journal-title":"JNMA."},{"issue":"2","key":"e_1_2_7_13_1","first-page":"204","article-title":"Association between peritoneal protein excretion, peritonitis and D\/P phosphate, in patients on peritoneal dialysis","volume":"33","author":"Rodriguez\u2010Garcia VH","year":"2013","journal-title":"Nefrologia"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314659"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.5.1242"},{"issue":"5","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/089686080002000509","article-title":"Peritoneal transport characteristics, comorbid diseases and survival in CAPD patients","volume":"20","author":"Chung SH","year":"2000","journal-title":"Perit. Dial. Int."},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1177\/089686080302300214","article-title":"Influence of peritoneal transport rate, inflammation and fluid removal on nutritional status and clinical outcome in prevalent peritoneal dialysis patients","volume":"23","author":"Chung SH","year":"2003","journal-title":"Perit. Dial. Int."},{"issue":"1","key":"e_1_2_7_18_1","first-page":"77","article-title":"Solute transport at the start of peritoneal dialysis and the risk of peritonitis","volume":"22","author":"Golembiewska E","year":"2013","journal-title":"Adv Clin Exp Med."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2008.08.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009020213"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/089686080802800309","article-title":"Patient and technique survival and factors affecting mortality on peritoneal dialysis in Turkey: 12 years' experience in a single centre","volume":"28","author":"Sipahioglu MH","year":"2008","journal-title":"Perit. Dial. Int."},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/089686080102100207","article-title":"Long\u2010term CAPD survival and analysis of mortality risk factors: 12\u2010year experience of a single Mexican center","volume":"21","author":"Cueto\u2010Manzano AM","year":"2000","journal-title":"Perit. Dial. Int."},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/089686089401400205","article-title":"The effect of serum albumin at the start of continuous ambulatory peritoneal dialysis treatment on patient survival","volume":"14","author":"Struijk DG","year":"1993","journal-title":"Perit. Dial. Int."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00326"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1681\/ASN.V1351307","article-title":"Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomised, controlled trial","volume":"13","author":"Paniagua R","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.9.1313"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/089686080802800114","article-title":"High peritoneal permeability is not associated with higher mortality or technique failure in patients on automated peritoneal dialysis","volume":"28","author":"Yang X","year":"2008","journal-title":"Perit. Dial. Int."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01910309"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.11694"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00334"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.12.023"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7111"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01655.x"},{"issue":"3","key":"e_1_2_7_34_1","first-page":"563","article-title":"Immunosuppressive and anti\u2010inflammatory effects of nicotine administered by patch in an animal model","volume":"11","author":"Kalra R","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-008-8078-6"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.03.025"},{"issue":"1234","key":"e_1_2_7_37_1","first-page":"U1977","article-title":"Current and former smoking increases mortality in patients on peritoneal dialysis","volume":"119","author":"Braatvedt GD","year":"2006","journal-title":"N. Z. Med. J."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00860.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00072"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.13063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:02:20Z","timestamp":1695009740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/nep.13063"],"URL":"https:\/\/doi.org\/10.1111\/nep.13063","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"type":"print","value":"1320-5358"},{"type":"electronic","value":"1440-1797"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2016-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}