{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:42:01Z","timestamp":1761709321374,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["545202","1021460"],"award-info":[{"award-number":["545202","1021460"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000975","name":"Kidney Health Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008713","name":"Diabetes Australia Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We assessed associations between cardiometabolic risk factors and estimated glomerular filtration rate (eGFR) decline according to baseline albuminuria to identify potential treatment targets in Indigenous Australians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The eGFR Follow\u2010up Study is a longitudinal cohort of 520 Indigenous Australians. Linear regression was used to estimate associations between baseline cardiometabolic risk factors and annual Chronic Kidney Disease Epidemiology Collaboration eGFR change (mL\/min per 1.73m<jats:sup>2<\/jats:sup>\/year), among those classified with baseline normoalbuminuria (urine albumin\u2010to\u2010creatinine ratio (uACR) &lt;3 mg\/mmol; <jats:italic>n<\/jats:italic> = 297), microalbuminuria (uACR 3\u201330 mg\/mmol; <jats:italic>n<\/jats:italic> = 114) and macroalbuminuria (uACR \u226530 mg\/mmol; <jats:italic>n<\/jats:italic> = 109).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median of 3 years follow\u2010up, progressive declines of the age\u2010 and sex\u2010adjusted mean eGFR were observed across albuminuria categories (\u22122.0 [\u22122.6 to \u20131.4], \u22122.5 [\u22123.7 to \u22121.3] and \u22126.3 [\u22127.8 to \u22124.9] mL\/min per 1.72m<jats:sup>2<\/jats:sup>\/year). Although a borderline association was observed between greater baseline haemoglobin A<jats:sub>1c<\/jats:sub> and eGFR decline in those with macroalbuminuria (<jats:italic>P<\/jats:italic> = 0.059), relationships were not significant in those with microalbuminuria (<jats:italic>P<\/jats:italic> = 0.187) or normoalbuminuria (<jats:italic>P<\/jats:italic> = 0.23). Greater baseline blood pressure, C\u2010reactive protein, waist\u2010to\u2010hip ratio and lower high\u2010density lipoprotein cholesterol showed non\u2010significant trends with greater eGFR decline in the presence of albuminuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over a 3 year period, marked eGFR decline was observed with greater baseline albuminuria. Cardiometabolic risk factors were not strong predictors for eGFR decline in Indigenous Australians without albuminuria. Longer follow\u2010up may elucidate the role of these predictors and other mechanisms in chronic kidney disease progression in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13073","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T03:36:47Z","timestamp":1494819407000},"page":"682-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Contribution of cardiometabolic risk factors to estimated glomerular filtration rate decline in <scp>I<\/scp>ndigenous <scp>A<\/scp>ustralians with and without albuminuria \u2010 the eGFR Follow\u2010up Study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4284-1716","authenticated-orcid":false,"given":"Elizabeth LM","family":"Barr","sequence":"first","affiliation":[{"name":"Menzies School of Health Research  Darwin North Territory Australia"},{"name":"Baker Heart and Diabetes Institute  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Barzi","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research  Darwin North Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-4156","authenticated-orcid":false,"given":"Jaquelyne T","family":"Hughes","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research  Darwin North Territory Australia"},{"name":"Department of Medicine Royal Darwin Hospital  Darwin North Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Jerums","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Austin Health  Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerin","family":"O'Dea","sequence":"additional","affiliation":[{"name":"Nutrition and Population Health University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-3918","authenticated-orcid":false,"given":"Alex DH","family":"Brown","sequence":"additional","affiliation":[{"name":"South Australian Health and Medical Research Institute  Adelaide South Australia Australia"},{"name":"Sansom Institute Health Research University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif I","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research  Darwin North Territory Australia"},{"name":"Department of Endocrinology Austin Health  Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham RD","family":"Jones","sequence":"additional","affiliation":[{"name":"SydPath St Vincent's Hospital  Sydney New South Wales Australia"},{"name":"Department of Medicine University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-4821","authenticated-orcid":false,"given":"Paul D","family":"Lawton","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research  Darwin North Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashim","family":"Sinha","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology Cairns Base Hospital  Cairns Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8058-6977","authenticated-orcid":false,"given":"Richard J","family":"MacIsaac","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"},{"name":"St Vincent's Hospital  Melbourne, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Cass","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research  Darwin North Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise J","family":"Maple\u2010Brown","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research  Darwin North Territory Australia"},{"name":"Department of Medicine Royal Darwin Hospital  Darwin North Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Australian Institute of Health and Welfare.Chronic kidney disease in Aboriginal and Torres Strait Islander People2011. 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