{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:34:19Z","timestamp":1771533259865,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102016R1D1A1B03934173"],"award-info":[{"award-number":["NRF\u20102016R1D1A1B03934173"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Cyst infection (CI) is a common problem in patients with autosomal dominant polycystic kidney disease (ADPKD). Localization is of great importance in CI. We describe the clinical experience with [18F] FDG\u2010labelled white\u2010blood cell (WBC) PET\/CT in detecting CI in ADPKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen ADPKD patients (M:F = 7:12) suspected of having CI were enrolled in this prospective study. All underwent WBC\u2010PET\/CT and MRI or CT. The degree of their WBC accumulation was evaluated from the maximal standardized uptake value of cystic wall.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cyst infection was diagnosed in 14 cases [definite (<jats:italic>n<\/jats:italic> = 6), probable (<jats:italic>n<\/jats:italic> = 1), or possible (<jats:italic>n<\/jats:italic> = 7); kidney (<jats:italic>n<\/jats:italic> = 11), or liver (<jats:italic>n<\/jats:italic> = 3)]. There was no difference in fever or laboratory findings (White blood cell count, C\u2010reactive protein, culture results, and eGFR). The blood culture was positive only in a subset of CI patients (<jats:italic>n<\/jats:italic> = 4). Cyst fluid culture yielded bacterial growth in 80% of aspirates. WBC\u2010PET\/CT detected 64% of CI cases, whereas conventional imaging, 50%. WBC\u2010PET\/CT showed false\u2010positive results in two of five cases with no CI. The reasons for false negatives with WBC\u2010PET\/CT were poor host immune reaction, low virulence, or prior antibiotic therapy. Haemorrhagic cysts were the most common cause of false positivity in WBC\u2010PET\/CT. However, WBC\u2010PET\/CT detected CI in three cases, in which the conventional imaging failed to find CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical information may play little role in the diagnosis of CI. WBC\u2010PET\/CT can be used to detect CI with better sensitivity in ADPKD patients, circumventing the exposure to contrast media.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13080","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T23:06:42Z","timestamp":1496272002000},"page":"661-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical experience with white blood cell\u2010PET\/CT in autosomal dominant polycystic kidney disease patients with suspected cyst infection: A prospective case series"],"prefix":"10.1111","volume":"23","author":[{"given":"Hyunsuk","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hallym University Medical center, Chuncheon Sacred Heart Hospital  Chuncheon\u2010si Gangwon\u2010do South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Kyu","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University, Boramae Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayne Cho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Armed Forces Capital Hospital  Seongnam\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seokwoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soojin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho\u2010young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Bundang Seoul National University College of Medicine  Seongnam\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Hwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Truewordsclinic  Incheon\u2010si Gyeonggi\u2010do South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curie","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"issue":"290","key":"e_1_2_8_2_1","first-page":"477","article-title":"Polycystic kidney disease re\u2010evaluated: a population\u2010based study","volume":"79","author":"Davies F","year":"1991","journal-title":"Q. 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