{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:11:41Z","timestamp":1792098701241,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300618"],"award-info":[{"award-number":["81300618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Calciphylaxis is a severe complication of advanced chronic kidney disease (CKD). Sodium thiosulphate (STS), an antioxidant and calcium chelating agent, has been used for the treatment of calciphylaxis. However, its efficacy and safety have not been systematically analysed and evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, EMBASE, and the Cochrane Library database were systematically searched for case report or cases series on use of STS for calciphylaxis published between July 1974 and October 2016. We extracted data on clinical characteristics, laboratory tests result and medication use. The effective treatment was defined as improvement in skin lesion cicatrisation or pain relief without death. Non\u2010responding effects were defined as stable skin lesions without remission or exacerbation of the disease in patients who remained alive. All\u2010cause mortality after STS treatment was defined as death due to exacerbations of calciphylaxis or other complications of advanced CKD. We compared the baseline parameters of the patients as well as the efficacy and mortality of the STS therapy between case report and multi\u2010case reports. Statistical analyses were performed using SPSS 19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 83 papers were screened, 45 of them (<jats:italic>n<\/jats:italic> = 358) met the inclusion criteria, including 36 case reports (<jats:italic>n<\/jats:italic> = 64) and nine multi\u2010case reports (<jats:italic>n<\/jats:italic> = 294). The mean age of the patients with calciphylaxis was 58 \u00b1 14 years (range 26\u201391 years). They were female predominant, accounting for 74.1%. Among the patients with calciphylaxis, 96.1% patients were on dialysis with median dialysis vintage of 44.5 months (range 24\u201384 months). STS was effective in 70.1% of patients, 37.6% patients died. The proportion of patients with sepsis was higher among those who received intravenous STS. There was no significant difference in efficacy between the different STS administration methods (<jats:italic>P<\/jats:italic> = 0.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the study was unable to assess the efficacy of sodium thiosulphate alone in the treatment of calciphylaxis, it still reveals a promising role of STS as an effective therapy for calciphylaxis. Further prospective studies to define the optimal therapy for calciphylaxis are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13081","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T03:46:42Z","timestamp":1497239202000},"page":"669-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Systematic review of sodium thiosulfate in treating calciphylaxis in chronic kidney disease patients"],"prefix":"10.1111","volume":"23","author":[{"given":"Ting","family":"Peng","sequence":"first","affiliation":[{"name":"Renal Division and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China (Chengdu, 610072)  China"},{"name":"School of Medicine University of Electronic Science and Technology of China  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Renal Division and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China (Chengdu, 610072)  China"},{"name":"School of Medicine University of Electronic Science and Technology of China  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of Sydney  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jun","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of Sydney  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisen","family":"Li","sequence":"additional","affiliation":[{"name":"Renal Division and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China (Chengdu, 610072)  China"},{"name":"School of Medicine University of Electronic Science and Technology of China  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China (Chengdu, 610072)  China"},{"name":"School of Medicine University of Electronic Science and Technology of China  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Hong","sequence":"additional","affiliation":[{"name":"Renal Division and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China (Chengdu, 610072)  China"},{"name":"The George Institute for Global Health University of Sydney  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00803.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2014.09.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70003-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-139X.2002.00052.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-014-2910-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2010.00738.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh305"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/982854"},{"key":"e_1_2_9_11_1","first-page":"8","article-title":"Sodium thiosulfate\u2010based treatment in calcific uremic arteriolopathy: a consecutive case series","volume":"75","author":"Sood AR","year":"2011","journal-title":"Clin. 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