{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:39:43Z","timestamp":1773427183159,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A low\u2010protein diet (LPD), particularly, very low\u2010protein diet (VLPD) is expected for reno\u2010protection in advanced chronic kidney disease, including diabetic nephropathy. We previously also demonstrated that a VLPD clearly improved advanced diabetic nephropathy in a type 2 diabetes and obesity rat. However, clinically, an everyday long\u2010term VLPD contributes to poor adherence, which may be related to controvertial results of an LPD on the suppression for diabetic nephropathy, and has nutritional issues, such as sarcopenia or protein\u2010energy wasting. The aim of this study is to elucidate the reno\u2010protective effect of a cyclic and intermittent VLPD, not an everyday VLPD, against the advanced experimental diabetic nephropathy. Diabetic male Wistar fatty (<jats:italic>fa\/fa<\/jats:italic>) rats (WFRs) were treated with a standard diet (STD; 23.84% protein) or a cyclic and intermittent VLPD (5.77% protein) consisting of an STD for 3\u2009days and a VLPD for 4\u2009days a week for 20\u2009weeks beginning at 24\u2009weeks of age. A cyclic and intermittent VLPD significantly improved renal hypertrophy, and significantly decreased urinary albumin and liver\u2010type fatty acid binding protein (L\u2010FABP) excretion without changes in body weight or exacerbation of HbA1c levels in diabetic rats. Additionally, diabetes\u2010induced renal injuries including fibrosis, tubular cell damage and inflammation were significantly ameliorated by a cyclic and intermittent VLPD in diabetic rats. Thus, based on our experimental data, a cyclic and intermittent VLPD may be a dietary regimen that is easy to continue and has less risk of malnutrition, compared to an everyday long\u2010term VLPD, against advanced diabetic nephropathy.<\/jats:p>","DOI":"10.1111\/nep.13152","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T14:02:38Z","timestamp":1502546558000},"page":"1030-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cyclic and intermittent very low\u2010protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar fatty (<i>fa\/fa<\/i>) rats, an animal model of type 2 diabetes and obesity"],"prefix":"10.1111","volume":"22","author":[{"given":"Munehiro","family":"Kitada","sequence":"first","affiliation":[{"name":"Department of Diabetology and Endocrinology Kanazawa Medical University  Uchinada Japan"},{"name":"Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Monnno","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Kanasaki","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology Kanazawa Medical University  Uchinada Japan"},{"name":"Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Koya","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology Kanazawa Medical University  Uchinada Japan"},{"name":"Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i3.342"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002934"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1467-8"},{"key":"e_1_2_7_5_1","first-page":"CD00218","article-title":"Protein restriction for diabetic renal disease","author":"Robertson L","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100995"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3925-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2016.26"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00422.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2005.09.010"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.13152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:36:17Z","timestamp":1695551777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,16]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/nep.13152"],"URL":"https:\/\/doi.org\/10.1111\/nep.13152","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,16]]},"assertion":[{"value":"2017-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}