{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:23Z","timestamp":1787015843411,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012128","name":"Austin Medical Research Foundation","doi-asserted-by":"publisher","award":["Grant 2008"],"award-info":[{"award-number":["Grant 2008"]}],"id":[{"id":"10.13039\/100012128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Levels of plasma markers of myocardial fibrosis (galectin\u20103), stretch (B\u2010type natriuretic peptide (BNP)) and injury (high\u2010sensitivity troponin T (hs\u2010TnT)) are affected by haemodialysis, residual renal function (RRF) and cardiac pathology. We aimed to determine the association of RRF, urine output and haemodialysis itself on cardiac biomarkers in haemodialysis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult haemodialysis patients underwent venesection pre\u2010 and post\u2010haemodialysis then echocardiography and inter\u2010dialytic urine collection to calculate RRF (mL\/min per 1.73m\n                      <jats:sup>2<\/jats:sup>\n                      ) and urine output (mL\/day). Galectin\u20103, BNP\u201032, NT\u2010ProBNP and hs\u2010TnT levels were compared across tertiles of echocardiographic parameters, RRF and urine output using the non\u2010parametric test for trend across ordered groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three patients (17 male) with mean age 67.7\u00b113.8\u2009years and median (interquartile range) dialysis duration 13.6 (9.8\u201319.1) months participated. Galectin\u20103 was substantially lower following haemodialysis: 55\u2009ng\/mL (47\u201370) versus 23\u2009ng\/mL (19\u201327,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), but other biomarkers changed little. By increasing RRF tertile, post\u2010dialysis galectin\u20103 was 32.6\u2009ng\/mL (23.7\u201336.6), 21.9\u2009ng\/mL (19.0\u201323.2) and 19.0\u2009ng\/mL (16.9\u201321.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001); NT\u2010ProBNP was 10\u2009192\u2009ng\/L (2303\u201321\u2009504), 2037\u2009ng\/L (1224\u201310\u2009795) and 1481\u2009ng\/L (172\u20132890,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.016). Results were similar for daily urine volume, but measured echocardiographic parameters were not associated with biomarker concentrations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma concentration of galectin\u20103 is reduced by the haemodialysis procedure. Lower RRF and urine volume are strongly associated with higher levels of galectin\u20103 and NT\u2010Pro\u2010BNP. These associations are important to the clinical interpretation of these biomarker levels in haemodialysis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.13179","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T09:36:35Z","timestamp":1507887395000},"page":"1131-1138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of haemodialysis and residual renal function on serum levels of galectin\u20103, B\u2010type natriuretic peptides and cardiac troponin T"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1665-3455","authenticated-orcid":false,"given":"Matthew A","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Nephrology Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medicine University of Melbourne  Melbourne Victoria 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