{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:56:27Z","timestamp":1791950187229,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["NHMRC APP631507"],"award-info":[{"award-number":["NHMRC APP631507"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Prenatal exposure to alcohol has adverse ramifications on foetal development resulting in developmental abnormalities and major congenital anomalies. Experimental studies have documented effects on kidney structure and function among offspring exposed to alcohol during foetal life; however, human evidence is scarce. Thus, the present study aimed to determine the development of CKD among a cohort of 30\u2010year\u2010old Australian offspring whose mothers reported consumption of alcohol during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study sample comprised 1626 offspring of the Australia cohort study (MUSP) whose serum creatinine was assessed at 30 years of age and CKD was categorized from stage 1 to stage 5 based on their level of eGFR following the CKD\u2010EPI definition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven percent (<jats:italic>n<\/jats:italic> = 111) of offspring had mild (stage 2) CKD at 30 years. The overall adjusted odds of CKD were 2.10 (95% CI 1.02 to 4.33) for offspring of moderate to heavy drinking mothers in late pregnancy, 1.59 (0.69 to 3.66) for early pregnancy and 1.23 (0.75 to 2.04) for pre\u2010pregnancy. The association was higher for female offspring\u20142.84 (1.07 to 7.54) for late pregnancy and 2.94 (1.10 to 7.88) for early pregnancy. Higher but insignificant odds were found for male offspring at late pregnancy 1.51 (0.49 to 4.73) only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal alcohol exposure during early and late pregnancy is associated with development of mild CKD in their offspring at 30 years. This association is stronger for female than male offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13206","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T09:36:43Z","timestamp":1513244203000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: Observation from a birth cohort study"],"prefix":"10.1111","volume":"24","author":[{"given":"Sumon K","family":"Das","sequence":"first","affiliation":[{"name":"Institute for Social Science Research, School of Social Science The University of Queensland  Brisbane Queensland Australia"},{"name":"Nutrition and Clinical Services Devision, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold D","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Mater Clinical School, School of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Mater Medical Research Institute  South Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Alati","sequence":"additional","affiliation":[{"name":"Institute for Social Science Research, School of Social Science The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Al Mamun","sequence":"additional","affiliation":[{"name":"Institute for Social Science Research, School of Social Science The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197709082971003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0259"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91092-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1542\/peds.63.6.886","article-title":"Renal anomalies in fetal alcohol syndrome","volume":"63","author":"Qazi Q","year":"1979","journal-title":"Pediatrics"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260400024021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.04.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000252973"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001694"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13114"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05597.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90316.2008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010040368"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1542\/peds.94.2.209","article-title":"Incidence of renal anomalies in children prenatally exposed to ethanol","volume":"94","author":"Taylor CL","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00858439"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi119"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu234"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.11468"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2012.45"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-014-0690-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_8_22_1","unstructured":"Australian Institute of Health and Welfare.Alcohol Use (NDSHS 2013 Key Findings). 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