{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:27:09Z","timestamp":1782602829691,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Previous studies have suggested a higher incidence of urologic malignancies in end\u2010stage renal disease (ESRD) patients. However, incidence trends of urologic malignancies in ESRD patients remain unclear. The aims of the present study were: (i) to investigate the pooled incidence\/incidence trends; and (ii) to assess the risk of urologic malignancies in ESRD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted using MEDLINE, EMBASE and Cochrane Database from inception through April 2017. Studies that reported incidence or odds ratios of urologic malignancies among ESRD patients were included. Pooled odds ratios (OR) and 95%CI were calculated using a random\u2010effect model. The protocol for this meta\u2010analysis is registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42017067687).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen observational studies with 1 931 073 ESRD patients were enrolled. The pooled estimated incidence of kidney cancer and urothelial cancers (carcinomas of the bladder, ureters, and renal pelvis) in ESRD patients were 0.3% (95%CI: 0.2\u20130.5%) and 0.5% (95%CI: 0.3\u20130.8%), respectively. Meta\u2010regression showed significant positive correlation between incidence of urologic malignancies in ESRD patients and year of study (slopes = +0.05 and +0.07, <jats:italic>P &lt;<\/jats:italic> 0.001 for kidney cancer and urothelial cancers, respectively). Compared to non\u2010ESRD status, ESRD was significantly associated with both kidney cancer (pooled OR 6.04; 95% CI 4.70\u20137.77) and urothelial cancers (pooled OR 4.37; 95% CI 2.40\u20137.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates a significant association between ESRD and urologic malignancies. The overall estimated incidence rates of kidney cancer and urothelial cancers are 0.4% and 0.5%, respectively. There is a significant positive correlation between the incidence of urologic malignancies and year of study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13209","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T13:36:44Z","timestamp":1513172204000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between urologic malignancies and end\u2010stage renal disease: A meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Panagiotis","family":"Kompotiatis","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-3604","authenticated-orcid":false,"given":"Charat","family":"Thongprayoon","sequence":"additional","affiliation":[{"name":"Department of Internal 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