{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:16:40Z","timestamp":1783538200974,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774106"],"award-info":[{"award-number":["81774106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine whether a correlation exists between interleukin\u20108 receptor polymorphisms and urinary tract infection (UTI) susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched electronic databases including PubMed, Embase, China National Knowledge Infrastructure, and Web of Science up to 5 November 2017 to select appropriate studies that focused on C\u2010X\u2010C chemokine receptor type 1 and\/or 2 (<jats:italic>CXCR1<\/jats:italic>, <jats:italic>CXCR2)<\/jats:italic> polymorphisms with susceptibility to UTI. Eight case\u2010control studies including 2085 patients with UTI and 2012 controls were enrolled in this study. Seven studies of <jats:italic>CXCR1<\/jats:italic> rs2234671 and two studies of rs3138086 were included in the meta\u2010analyses. Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were synthesized using fixed\u2010effects or random\u2010effects model according to heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant correlations were found between <jats:italic>CXCR1<\/jats:italic> rs2234671 and rs3138086 polymorphisms and UTI susceptibility. However, subgroup analysis showed that rs2234671 was associated with an increased risk of UTI under allelic comparisons (C vs. G, OR = 1.95, 95% CI = 1.07\u20133.55), heterozygous model (GC vs. GG, OR = 1.93, 95% CI = 1.06\u20133.50), and dominant model (GC + CC vs. GG, OR = 1.98, 95% CI = 1.07\u20133.69) in children, especially in paediatric patients with acute pyelonephritis (allelic, OR = 2.43, 95% CI = 1.28\u20134.60; heterozygous, OR = 2.40, 95% CI = 1.24\u20134.62; dominant, OR = 2.48, 95% CI = 1.26\u20134.88). Furthermore, these results remained the same after eliminating paediatric patients with vesicoureteral reflux.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>CXCR1<\/jats:italic> rs2234671 polymorphism might be associated with an increased risk of UTI in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13260","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:23:17Z","timestamp":1522027397000},"page":"464-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association between interleukin 8\u2010receptor gene (CXCR1 and CXCR2) polymorphisms and urinary tract infection: Evidence from 4097 subjects"],"prefix":"10.1111","volume":"24","author":[{"given":"Shi\u2010Sheng","family":"Han","sequence":"first","affiliation":[{"name":"Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Qiu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2017.07.018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2017.07.002"},{"key":"e_1_2_6_4_1","first-page":"25","article-title":"The genetics of urinary tract infections and the innate defense of the kidney and urinary tract","volume":"5","author":"Ambite I","year":"2016","journal-title":"J. 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