{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:54:26Z","timestamp":1790895266694,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T00:00:00Z","timestamp":1532822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of glomerulonephritis with monoclonal immunoglobulin (Ig) A deposits as a form of monoclonal gammopathy of renal significance (MGRS) caused by monoclonal immunoglobulins without blood disorders in a 41\u2010year\u2010old woman. She developed lower leg oedema and was hospitalized because of nephrotic syndrome. Serum and urine were negative for M protein, and the free light chain \u03ba\/\u03bb ratio was within the normal range. Renal histopathological findings included mesangial proliferation, endocapillary cell proliferation, and a double\u2010contour appearance of the capillary walls. Immunofluorescent staining indicated IgA and C3 deposits on the mesangium and capillary walls. Only \u03bb chain and IgA1 deposits were noted. Fine granular sub\u2010endothelial deposits with no specific structure were observed under electron microscopy. The patient was diagnosed with IgA\u2013proliferative glomerulonephritis with monoclonal immunoglobulin deposits (IgA\u2010PGNMID). The patient had decreased urine protein and sediment erythrocytes after she underwent two rounds of steroid pulse therapy and oral steroid therapy, but proteinuria and haematuria still remained. Four months later, the patient was administered 50 mg\/day cyclosporine (CsA), and proteinuria and haematuria dramatically decreased. Only a few case reports have been published on IgA\u2010PGNMID. This case is rare in that the patient achieved successful treatment using a combination of steroids and CsA.<\/jats:p>","DOI":"10.1111\/nep.13261","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T06:25:19Z","timestamp":1522045519000},"page":"787-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful treatment with steroid and cyclosporine A in a patient with immunoglobulin A\u2013proliferative glomerulonephritis with monoclonal immunoglobulin deposits"],"prefix":"10.1111","volume":"23","author":[{"given":"Keisuke","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Medicine Kidney Center Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Makabe","sequence":"additional","affiliation":[{"name":"Department of Medicine Kidney Center Tokyo Women's Medical University  Tokyo 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Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Medicine Kidney Center Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekiko","family":"Taneda","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Kidney Center Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosaku","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Medicine Kidney Center Tokyo Women's Medical University  Tokyo 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