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The molecular mechanisms behind are the development of alterations in glycogen synthase kinase 3 signalling, G2 cell cycle progression arrest, alterations in inositol and prostaglandin signalling pathways, and dysregulated trafficking and transcription of aquaporin 2 water channels.<\/jats:p>","DOI":"10.1111\/nep.13263","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T01:11:14Z","timestamp":1522631474000},"page":"897-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Lithium and nephrotoxicity: Unravelling the complex pathophysiological threads of the lightest metal"],"prefix":"10.1111","volume":"23","author":[{"given":"Justin","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Renal Medicine University Hospital Geelong  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Desmond","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine University Hospital Geelong  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"Deakin University, IMPACT Strategic Research Centre School of Medicine, Barwon Health  Geelong Victoria Australia"},{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, The Department of Psychiatry and The Florey Institute for Neuroscience and Mental Health University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.116.193789"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61703-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867412437346"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-017-0089-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31823607db"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00316-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.43"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-016-0068-y"},{"key":"e_1_2_8_10_1","article-title":"Lithium and renal impairment: A review on a still hot topic","author":"Nielsen RE","year":"2018","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1977.102"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090169"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1181439"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2796"},{"key":"e_1_2_8_15_1","article-title":"AJKD atlas of renal pathology: Lithium nephrotoxicity","volume":"69","author":"Fogo AB","year":"2017","journal-title":"Am. 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