{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:48:11Z","timestamp":1790894891666,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Friendship Hospital"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the prognostic value of baseline SOFA coagulation score (SOFA\u2010CS) and change in platelet counts in patients with severe acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a secondary analysis from the Randomized Evaluation of Normal versus Augmented Level of RRT (RENAL) study. The primary endpoint was all\u2010cause mortality at 90\u2009days after randomization. The association between baseline SOFA\u2010CS, changes in platelet counts, process of care, and clinical outcomes were analyzed using multivariate Cox model adjusted for baseline variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The complete SOFA\u2010CS data were available in 1454 out of 1508 patients from the RENAL study. Among them, 708 patients had an abnormal SOFA\u2010CS (defined as SOFA\u2010CS\u2009\u2265\u20091), while 746 patients had normal SOFA\u2010CS at baseline (SOFA\u2010CS\u2009=\u20090). An abnormal SOFA\u2010CS was independently associated with an increased risk of death at 90\u2009days (HR\u2009=\u20091.27, 95% CI\u2009=\u20091.05\u20131.53, <jats:italic>P<\/jats:italic>\u2009=\u20090.015). An abnormal SOFA\u2010CS was associated with prolonged length of ICU stay and duration of mechanical ventilation as well. Furthermore, there was no significant association between changes in platelet counts in patients who survived beyond 4\u2009days and 90 day mortality (HR\u2009=\u20091.26, 95% CI\u2009=\u20090.29\u20135.56, <jats:italic>P<\/jats:italic>\u2009=\u20090.76). However, on multivariable analysis a decline of \u226560% (HR\u2009=\u20091.93, 95% CI\u2009=\u20091.23\u20133.05, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) was associated with 90 day mortality in patients who survived beyond the first 4\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the RENAL study, thrombocytopaenia is a common phenomenon in patients with severe AKI receiving CRRT. An abnormal baseline SOFA\u2010CS and reductions in platelet counts were associated with increased mortality at 90\u2009days.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13387","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T01:02:05Z","timestamp":1524618125000},"page":"518-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["SOFA coagulation score and changes in platelet counts in severe acute kidney injury: Analysis from the randomized evaluation of normal versus augmented level (RENAL) study"],"prefix":"10.1111","volume":"24","author":[{"given":"Jin","family":"Lin","sequence":"first","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gallagher","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Concord Repatriation General Hospital  Concord New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinaldo","family":"Bellomo","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Intensive Care Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Duan","sequence":"additional","affiliation":[{"name":"Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konlawi","family":"Trongtrakul","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine Vajira Hospital Navamindradhiraj University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Faculty of Medicine &amp; Health Sciences Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Renal Study Investigators and the Anzics Clincal Trials Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5965"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc4915"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000224227.70642.4F"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200209000-00016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(06)13"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447543"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001579"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200208000-00015"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1570080"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097286"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142931"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1057799"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902413"},{"key":"e_1_2_12_16_1","first-page":"58","article-title":"The RENAL (randomised evaluation of normal vs. augmented level of replacement therapy) study: Statistical analysis plan","volume":"11","author":"Finfer S","year":"2009","journal-title":"Crit. 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