{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:13:26Z","timestamp":1773299606153,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102016R1D1A1B03934173"],"award-info":[{"award-number":["NRF\u20102016R1D1A1B03934173"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to describe the baseline characteristics of autosomal\u2010dominant polycystic kidney disease (ADPKD) in a cohort of Korean patients with chronic kidney disease (CKD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From April 2011 to February 2016, patients with CKD stage 1\u20135 (pre\u2010dialysis) were enrolled as an ADPKD sub\u2010cohort of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease. Baseline characteristics, the correlation of kidney and liver volume and kidney function and the factors associated with kidney function were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 364 ADPKD patients with a mean estimated glomerular filtration rate (eGFR) of 68.1 \u00b1 33.3 mL\/min per 1.73 m<jats:sup>2<\/jats:sup> (50.5% male with a mean age of 47.0 \u00b1 10.6 years) were enrolled from nine hospitals in Korea. Initially, 55.8% of the patients were asymptomatic, and pain was the most common symptom (12.9%); 87.6 and 77.5% of the patients had hypertension and hepatic cysts, respectively. The height\u2010adjusted total kidney volumes (htTKV) were higher in male patients than in female patients. In contrast, the height\u2010adjusted total liver volumes were higher in female patients than in male patients. The decrease rate of eGFR depending on Log(htTKV) was larger in the group aged between 41 and 50 years than the other age groups. Older age, a higher 24\u2010h urine protein excretion, larger htTKV and hyperuricemia were independently associated with lower eGFR, whereas using febuxostat was independently associated with higher eGFR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This sub\u2010cohort will provide clinical characteristics and outcomes of Korean ADPKD patients, which can be compared with those of other previous cohorts. We have identified factors associated with advanced\u2010stage CKD in Korean patients with ADPKD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13407","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T05:44:39Z","timestamp":1527227079000},"page":"422-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Baseline characteristics of the autosomal\u2010dominant polycystic kidney disease sub\u2010cohort of the KoreaN cohort study for outcomes in patients with chronic kidney disease"],"prefix":"10.1111","volume":"24","author":[{"given":"Hyunsuk","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hallym University Medical Center Chuncheon Sacred Heart Hospital  Chuncheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junga","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue K","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kook H","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University Busan Paik Hospital  Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaeni","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, The Catholic University of Korea  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curie","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun K","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University Boramae Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"e_1_2_7_3_1","first-page":"49","volume-title":"Problems in Diagnosis and Management of PolycysticKkidney Disease","author":"Torres VE","year":"1985"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(83)80044-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011101032"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2009.12.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00185.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054341"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04310709"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.558"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092232"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","unstructured":"Heyer CM Sundsbak JL Abebe KZ et al. for the HALT PKD and Q8 CRISP Investigators. 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