{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:38:53Z","timestamp":1777498733282,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"ABSTRACT<\/jats:title>Aim<\/jats:title>ABO\u2010incompatible (ABOi) kidney transplantation (KT) has become a routine procedure with graft survival rates comparable to those of ABO\u2010compatible KT. However, the clinical significance of the isoagglutinin titre in ABOi KT remains uncertain. Therefore, in this study, we analysed the clinical outcomes of ABOi KT according to the baseline and post\u2010operative isoagglutinin titre.<\/jats:p><\/jats:sec>Methods<\/jats:title>All patients who received ABOi KT between 2009 and 2013 were reviewed and followed up until December 2016. The patients were classified according to baseline (<1:128 or \u22651:128) and post\u2010operative rebound isoagglutinin titre (<1:16 or \u22651:16), and the clinical outcomes of KT were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with a high baseline isoagglutinin titre showed a poor titre reduction rate (1.48\u2009\u00b1\u20090.41 vs<\/jats:italic> 1.32\u2009\u00b1\u20090.34, P<\/jats:italic> =\u20090.008), and more patients experienced titre rebound \u22651:16 after KT (15.0% vs<\/jats:italic> 35.8%, P<\/jats:italic> =\u20090.002). The occurrence of both T\u2010cell\u2010mediated rejection and antibody\u2010mediated rejection did not show a significant difference (P<\/jats:italic> =\u20090.805 and 0.714, respectively). The rate of rejection\u2010free survival was not different among groups (P<\/jats:italic> =\u20090.680, log\u2013rank test). Furthermore, the rate of death\u2010censored graft survival was not different among groups (P<\/jats:italic> =\u20090.701, log\u2013rank test). Urinary tract infection was the most frequently reported infectious complication overall. The incidence of urinary tract infection, pneumonia and viral infections (BK virus and cytomegalovirus) was not different among groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In conclusion, high baseline isoagglutinin titre was associated with a high rebound isoagglutinin titre, low titre reduction rates and more sessions of plasmapheresis. However, the isoagglutinin titre may not be as important as it was in the past in ABOi KT if appropriate desensitization is performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13412","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T08:33:21Z","timestamp":1528360401000},"page":"654-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical significance of isoagglutinin titre with the current desensitization protocol in ABO\u2010incompatible kidney transplantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-2373","authenticated-orcid":false,"given":"Chung Hee","family":"Baek","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyosang","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Seok","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duck Jong","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Surgery, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Kil","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"231","article-title":"Human ABO\u2010incompatible living donor renal homografts","volume":"28","author":"Alexandre GP","year":"1985","journal-title":"Neth. J. Med."},{"key":"e_1_2_6_3_1","first-page":"208","article-title":"Lessons learned from ABO\u2010incompatible living donor kidney transplantation: 20 years later","volume":"2","author":"Squifflet JP","year":"2004","journal-title":"Exp. Clin. Transplant."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00234"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.144"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000312"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.05.026"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355855"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200011150-00011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000173647.43616.78"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200008270-00024"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03103.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12482"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004249"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21312"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.13412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.13412","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:19:04Z","timestamp":1694344744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/nep.13412"],"URL":"https:\/\/doi.org\/10.1111\/nep.13412","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,15]]},"assertion":[{"value":"2018-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}