{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:36:49Z","timestamp":1789609009132,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T00:00:00Z","timestamp":1544918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Cognitive dysfunction is reportedly highly prevalent among chronic kidney disease (CKD) patients. A variety of screening tools and neuropsychiatric batteries are used to quantify the magnitude and nature of this dysfunction. Our objective is to summarize the neurocognitive testing used, and determine what degree cognitive dysfunction is reported in CKD patients. All study designs published in English that contained participants who were either pre\u2010dialysis patients, haemodialysis (HD) or peritoneal dialysis (PD) patients or renal transplant recipients were considered. Reported comparative non\u2010CKD control data was also collected. All study designs were included. The search period encompassed articles from 1980 to May 2018. This review is registered with PROSPERO (CRD42018096568). Of the 1711 articles screened, 148 articles were relevant and used in the meta\u2010analysis. Commonly used assessments were The Mini\u2013Mental State Examination (MMSE), The Modified Mini\u2013Mental State Examination, the Trails Making Tests (TMT) forms A and B and components of the Wechsler Adult Intelligence Scale: Digit Span and Digit Symbol. Means for all assessments were adjusted using a random effects model to account for the differences in variance. Adjusted mean MMSE scores were significantly lower for both pre\u2010dialysis (26.08, <jats:italic>n<\/jats:italic> = 17 073) and HD (26.31, <jats:italic>n<\/jats:italic> = 3314) patients when compared to non\u2010CKD controls (28.21, <jats:italic>n<\/jats:italic> = 5226). PD (58.01 s, <jats:italic>n<\/jats:italic> = 859) and HD (56.04 s, <jats:italic>n<\/jats:italic> = 2344) patients also took significantly longer to complete the Trails Making Task A than non\u2010CKD controls (37.62 s, <jats:italic>n<\/jats:italic> = 4809). Patients with CKD, especially pre\u2010dialysis and those requiring dialysis, are likely to exhibit impairments in cognition that can be identified with specific screening neuropsychological assessments.<\/jats:p>","DOI":"10.1111\/nep.13448","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T07:20:22Z","timestamp":1533885622000},"page":"5-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Quantifying cognitive dysfunction across the spectrum of end\u2010stage kidney disease: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Jessica A.","family":"Vanderlinden","sequence":"first","affiliation":[{"name":"Centre for Neuroscience Studies Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Ross\u2010White","sequence":"additional","affiliation":[{"name":"Queen's University, Library Services  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Holden","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Khaled","family":"Shamseddin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Research Development Kingston General Hospital  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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