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CKD\u2010MBD is characterized by : (i) abnormal metabolism of calcium, phosphorus, parathyroid hormone (PTH), or vitamin D; (ii) abnormalities in bone turnover, mineralization, volume linear growth or strength; (iii) soft\u2010tissue calcifications, either vascular or extra\u2010osseous. Uremic vascular calcification and osteoporosis are the most common complications related to CKD\u2010MBD. Disregulated bone turnover by uremic toxin or secondary hyperparathyroidism disturbed bone mineralization and makes it difficult for calcium and inorganic phosphate to enter into bone, resulting in increased serum calcium and inorganic phosphate. Vascular calcification worsens by hyperphosphatemia and systemic inflammation. Since vitamin D deficiency plays an important role in renal osteodystrophy, supplement of nutritional vitamin D is important in treating uremic osteoporosis and vascular calcification at the same time. Its pleotropic effect improves the bone remodeling initiated by osteoblast and alleviates the risk factors for vascular calcification with less hypercalcemia than vitamin D receptor analogs. Therefore, nutritional vitamin D should be considered in managing CKDMBD.<\/jats:p>","DOI":"10.1111\/nep.13457","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T22:58:14Z","timestamp":1539039494000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Mineral bone disorders in chronic kidney disease"],"prefix":"10.1111","volume":"23","author":[{"given":"Yi\u2010Chou","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cardinal Tien Hospital, School of Medicine, Fu\u2010Jen Catholic University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medicine Fu\u2010Jen Catholic University Hospital, College of Medicine, Fu\u2010Jen Catholic University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medicine Fu\u2010Jen Catholic University Hospital, College of Medicine, Fu\u2010Jen Catholic University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-014-0189-0"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.03.022"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1886"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001769"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000470909"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00785.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09750913"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02680310"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S97637"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.07.015"},{"key":"e_1_2_14_12_1","first-page":"4003","article-title":"The parathyroid is a target organ for FGF23 in rats","volume":"117","author":"Ben\u2010Dov IZ","year":"2007","journal-title":"J. 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