{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:50:41Z","timestamp":1790329841946,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 106\u2010P02, 106\u2010S3357"],"award-info":[{"award-number":["NTUH 106\u2010P02, 106\u2010S3357"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX106\u201010633SI"],"award-info":[{"award-number":["NHRI\u2010EX106\u201010633SI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"publisher","award":["105\u20102314\u2010B\u2010002\u2010096\u2010MY3"],"award-info":[{"award-number":["105\u20102314\u2010B\u2010002\u2010096\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST, 104\u20102314\u2010B\u2010002\u2010119"],"award-info":[{"award-number":["MOST, 104\u20102314\u2010B\u2010002\u2010119"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute kidney injury (AKI) can increase the risk of developing incident chronic kidney disease (CKD). The severity, frequency and duration of AKI are crucial predictors of poor renal outcome. A repair process after AKI can be adaptive and kidney recovers completely after a mild injury. However, severe injury will lead to a maladaptive repair, which frequently progresses to nephron loss, vascular rarefaction, chronic inflammation and fibrosis. Although different mechanisms underlying AKI\u2010CKD transition have been extensively discussed, no definite intervention has been proved effective to block or to retard the transition until recently. In CKD, renin\u2010angiotensin system (RAS) inhibitor has been proved effective to slow down disease progression. Furthermore, RAS needs to be highlighted again in AKI\u2010CKD transition because recent animal studies have shown the activation of intra\u2010renal RAS after AKI, and RAS blockade can reduce the ensuing CKD and mortality. In patients with the complete renal recovery after AKI, administration of RAS inhibitor is associated with reduced risk of subsequent CKD as well. In this article, we will demonstrate the role of RAS in AKI\u2010CKD transition comprehensively. We will then emphasize the promising effect of RAS inhibitor on CKD prevention in patients recovering from AKI based on evidence from the bench to clinical research. All of these discussions will contribute to the establishment of reliable monitoring and therapeutic strategies for patients with functional recovery from AKI who can be most easily ignored.<\/jats:p>","DOI":"10.1111\/nep.13467","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T22:58:14Z","timestamp":1539039494000},"page":"121-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Role of renin\u2010angiotensin system in acute kidney injury\u2010chronic kidney disease transition"],"prefix":"10.1111","volume":"23","author":[{"given":"Yu\u2010Hsiang","family":"Chou","sequence":"first","affiliation":[{"name":"Renal Division, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital Jin\u2010Shan Branch  New Taipei City Taiwan"},{"name":"Graduate Institute of Physiology, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong\u2010Shinn","family":"Chu","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuei\u2010Liong","family":"Lin","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Physiology, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Integrated Diagnostics and Therapeutics National Taiwan University Hospital  Taipei Taiwan"},{"name":"Research Center for Developmental Biology and Regenerative Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30240-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00344-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009060636"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.813"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02140215"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10252"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.10.019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01120211"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.289"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.514"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11419"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1149-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.6.609"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195605312542203"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1214243"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2017.04.026"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2016.04.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.12.010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011303"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011161"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.050"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.09.009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2144"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2135"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12521"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.208"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00061.2009"},{"key":"e_1_2_7_31_1","first-page":"351","article-title":"Epigenetics in acute kidney injury","volume":"24","author":"Tang J","year":"2015","journal-title":"Curr. 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