{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:00:00Z","timestamp":1775070000793,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"am","delay-in-days":132,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","award":["WHO Reference 2014\/435380\u20100"],"award-info":[{"award-number":["WHO Reference 2014\/435380\u20100"]}],"id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006190","name":"Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the spectrum of chronic kidney disease (CKD) in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a large national in\u2010patient database covering 878 class three hospitals and involving 64.7 million adult patients in China from 2010 to 2015. The class 3 hospital in China is ranked as the top tier of medical system in China with at least 500 beds and the accreditation from health authorities. The specific causes of CKD were extracted from the International Classification of Diseases\u201010 codes of discharge diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4.5% of hospitalized patients (1.8 million) were identified as CKD, with an increased percentage from 2010 (3.7%) to 2015 (4.7%). Increasing trends of diabetic kidney disease and hypertensive nephropathy were observed from 2010 to 2015 (19.5% <jats:italic>vs<\/jats:italic> 24.3% and 11.5% <jats:italic>vs<\/jats:italic> 15.9%, respectively), especially for urban residents from north China. The proportion of obstructive nephropathy also increased gradually (10.3% in 2010 <jats:italic>vs<\/jats:italic> 15.6% in 2015) and constituted another important cause of CKD for patients, especially for those from south China and rural residents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The spectrum of CKD is changing in China, with variations over time and geographic regions, which has implication regarding developing the prevention strategy of CKD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13489","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T05:08:08Z","timestamp":1536556088000},"page":"725-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Spectrum of chronic kidney disease in China: A national study based on hospitalized patients from 2010 to 2015"],"prefix":"10.1111","volume":"24","author":[{"given":"Yu\u2010Ming","family":"Huang","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital, Peking University Institute of Nephrology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damin","family":"Xu","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital, Peking University Institute of Nephrology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyan","family":"Long","sequence":"additional","affiliation":[{"name":"China Standard Medical Information Research Center  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Shi","sequence":"additional","affiliation":[{"name":"China Standard Medical Information Research Center  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital, Peking University Institute of Nephrology  Beijing China"},{"name":"Peking University, Center for Data Science in Health and Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"China Standard Medical Information Research Center  Shenzhen China"},{"name":"Clinical Trial Unit First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeera","family":"Levin","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital, Peking University Institute of Nephrology  Beijing China"},{"name":"Peking\u2010Tsinghua Center for Life Sciences  Beijing PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60674-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60687-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.05.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61601-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60033-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp058318"},{"key":"e_1_2_7_10_1","first-page":"77","article-title":"The report about the registration of dialysis and transplantation in China 1999","volume":"17","author":"Dialysis and Transplantation Registration Group","year":"2001","journal-title":"Chin. 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