{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:07:08Z","timestamp":1774364828962,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009048","name":"Mrs. Hsiu-Chin Lee Kidney Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Autonomic dysfunction contributes to cardiovascular morbidity\/mortality and can be evaluated with heart rate variability (HRV). This study is to evaluate the prognostic significance of HRV on renal function in non\u2010dialysis chronic kidney disease (CKD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 326 non\u2010dialysis CKD patients in this prospective observational study. The median follow\u2010up period was 2.02\u2009years. Five\u2010minutes of electrocardiography recordings obtained at enrolment were reprocessed to assess HRV. Five frequency\u2010domain measures and one time\u2010domain measures were obtained. Rapid CKD progression was defined as annual estimated glomerular filtration rate (eGFR) loss over 30% per year or eGFR decline rate over 3\u2009mL\/min per 1.73\u2009m<jats:sup>2<\/jats:sup> per year. The prevalence of abnormal HRV, associated factors of HRV and impact of HRV on the risk of CKD progression were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The abnormality of HRV increased along with the severity of CKD. In patients with stage 5 CKD, the proportion of abnormal ln(low frequency power) (LF), ln(high frequency power) (HF), lnLF\/HF were 69.5, 52.8 and 50%, respectively. Associated factors of HRV included advanced CKD, diabetes mellitus, serum albumin, severe proteinuria, Beck Anxiety Inventory score, erythropoietin use, renin\u2010angiotensin system inhibitors and heart failure. Multivariate logistic regression model analysis revealed lower lnLF\/HF, hypertension and severe proteinuria were the risk factors of rapid CKD progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of autonomic dysfunction measured by HRV among each stage CKD patients is different. Most patients in advanced CKD stage have reduced values of HRV parameters. The estimation of lnLF\/HF also provided prognostic information on CKD progression in addition to classical risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13514","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T08:40:44Z","timestamp":1539765644000},"page":"806-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Heart rate variability as a predictor of rapid renal function deterioration in chronic kidney disease patients"],"prefix":"10.1111","volume":"24","author":[{"given":"Yu\u2010Hsiang","family":"Chou","sequence":"first","affiliation":[{"name":"Renal Division, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital Jin\u2010Shan Branch  New Taipei City Taiwan"},{"name":"Graduate Institute of Physiology, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Lieh","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Taiwan University Hospital  Yunlin Branch, Yunlin County Taiwan"},{"name":"Department of Psychiatry, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Research National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl C. 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