{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:07:59Z","timestamp":1775290079269,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"HeBei provincial Key Project of Medical Science","award":["20180186"],"award-info":[{"award-number":["20180186"]}]},{"name":"Key Research and Development Plan of HeBei Province","award":["18277709D"],"award-info":[{"award-number":["18277709D"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Pulmonary infection (PI) is the leading cause of death in patients with primary membranous nephropathy on immunosuppressive therapy. A rating score was thus developed to foresee the risk of PI in such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed the charts of the pertinent patients treated during the past 3 years either with (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929) or without PI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009304). Clinical and laboratory data, the usage of cyclosporin A (CysA), and occurrence of PI were recorded. Cox regression analysis and receiver operating characteristic (ROC) curve were respectively used to identify the risk factors and assess their clinical relevance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of PI was 8.7% at 82.1\u2009\u00b1\u200920.9\u2009days after the initiation of CysA regimen with a male predominance superimposed on smoking. Factors associated with PI were immunoglobulin G titer (hazard ratio\u2009=\u20094.56, 95% confidence interval\u2009=\u20092.31\u20138.95), plasma CysA concentration (3.71, 1.87\u20136.18), serum creatinine level (2.57, 1.31\u20135.82), CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD8\n                      <jats:sup>+<\/jats:sup>\n                      ratio (2.36, 1.26\u20136.06) and plasma albumin content (1.53, 1.05\u20133.25). These five factors, along with the male gender and smoking status, were granted different ratings after examined by the ROC curve and constituted the anticipating pulmonary infection in primary membranous nephropathy receiving CysA (AIM\u20107C) score. Accordingly, the respective percent composition of the infection and non\u2010infection group was 0, 11.1%, 72.2%, 16.7% and 91.7%, 8.3%, 0, 0 in the order of low, moderate, high and utmost risk. Furthermore, eight new cases of PI were successfully predicted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our AIM\u20107C score may therefore help to predict the onset and facilitate the prevention of PI, a potentially life\u2010threatening complication of the immunosuppressive therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.13544","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T02:23:25Z","timestamp":1543544605000},"page":"1009-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predicting risk of pulmonary infection in patients with primary membranous nephropathy on immunosuppressive therapy: The AIM\u20107C score"],"prefix":"10.1111","volume":"24","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology HeBei General Hospital ShiJiaZhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology the 4th Affiliated Hospital of HeBei Medical University ShiJiaZhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Ping","sequence":"additional","affiliation":[{"name":"The 2nd Department of Respiratory Diseases HeBei General Hospital ShiJiaZhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Office of Medical Records and Statistics HeBei General Hospital ShiJiaZhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"The 1st Department of Respiratory Diseases HeBei General Hospital ShiJiaZhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongzhen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nephrology Provincial Research Institute of Kidney Diseases ShiJiaZhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"MRI Division, Department of Radiology HeBei General Hospital ShiJiaZhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39576.709711.80"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60731-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr220"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1399-0012.1996.tb00657.x","article-title":"Molecular mechanisms of new immunosuppressants","volume":"10","author":"Halloran PF","year":"1996","journal-title":"Clin. Transplant."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590041484.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(03)00134-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000160742.91602.b7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806113382407"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250602"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140778"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06870909"},{"key":"e_1_2_7_13_1","first-page":"139","article-title":"Improving global outcomes (KDIGO) glomerulonephritis work group. KDIGO clinical practice guideline for glomerulonephritis","volume":"2","author":"Kidney Disease","year":"2012","journal-title":"Kidney Int."},{"key":"e_1_2_7_14_1","first-page":"467","article-title":"Expert panel on the immunosuppressive therapy in Chinese adults with nephrotic syndrome: The Chinese expert consensus","volume":"30","year":"2014","journal-title":"Chin. J. Nephrol."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12793"},{"key":"e_1_2_7_16_1","first-page":"E21","article-title":"Respiratory infection in the AIDS and immunocompromised patient","volume":"14","author":"Franquet T","year":"2004","journal-title":"Eur. Radiol."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000438024.10375.2d"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(00)00026-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000085046.39523.D5"},{"key":"e_1_2_7_20_1","first-page":"S30","article-title":"Systemic fungal infections in renal diseases","volume":"51","author":"Gandhi BV","year":"2005","journal-title":"J. Postgrad. Med."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000055547.93484.87"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-1812-2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12268"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02752333"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2014.05.008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/annrheumdis-2017-eular.5464","article-title":"Multicriteria decision analysis for developing new classification criteria for systemic lupus erythematosus","volume":"76","author":"Tedesch S","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000158728.14945.46"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.9707101"},{"key":"e_1_2_7_29_1","article-title":"Early infectious diseases specialty intervention is associated with shorter hospital stays and lower readmission rates: A retrospective cohort study","author":"Schmitt S","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2018.01.003"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810457"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.13544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.13544","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:30:00Z","timestamp":1775287800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,29]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/nep.13544"],"URL":"https:\/\/doi.org\/10.1111\/nep.13544","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,29]]},"assertion":[{"value":"2018-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}