{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:54:29Z","timestamp":1776891269928,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A significant proportion of patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are either steroid dependent or steroid resistant, requiring long\u2010term calcineurin inhibitors (CNI) use. Rituximab has more favourable safety profile. The present study was undertaken to evaluate the efficacy and safety of rituximab in CNI\u2010dependent patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational study conducted from July 2014 to February 2018. Steroid\u2010dependent nephrotic syndrome or steroid\u2010resistant nephrotic syndrome (biopsy proven MCD\/FSGS), who were CNI dependent were enrolled. Mean age at enrolment was 22.77\u2009\u00b1\u20097.45\u2009years. All patients received rituximab at a dose of 375\u2009mg\/m<jats:sup>2<\/jats:sup> at entry in the study. CD\u201019 levels were monitored monthly and patients having CD\u201019 levels &gt;5\/\u03bcL and\/or\u2009&gt;\u20091% received additional low\u2010dose (100\u2009mg) of rituximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 patients were followed up for 12\u2009months. At the end of 6 and 12\u2009months, 87.5% and 79.16% of the patients achieved remission, respectively. Eight (33.33%) patients developed relapse. The mean dose of rituximab in the first year was 791\u2009mg. The average cost of rituximab in the first year was 487.17$. Rituximab was well\u2010tolerated, with mild infusion reactions, respiratory tract infection and oral candidiasis in 5 (20.83%), 5 (20.83%) and 1 (4.17%) patient, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CD\u201019 targeted rituximab is a safe and cost\u2010effective agent in remission maintenance in adults with CNI dependent. Over three\u2010fourths of the patients with CNI\u2010dependent podocytopathy maintain clinical remission with CD\u201019 targeted rituximab therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13554","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T13:59:15Z","timestamp":1545832755000},"page":"1241-1247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Persistent CD\u201019 depletion by rituximab is cost\u2010effective in maintaining remission in calcineurin\u2010inhibitor dependent podocytopathy"],"prefix":"10.1111","volume":"24","author":[{"given":"Raja","family":"Ramachandran","sequence":"first","affiliation":[{"name":"Department of Nephrology PGIMER  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyita","family":"Bharati","sequence":"additional","affiliation":[{"name":"Department of Nephrology PGIMER  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-739X","authenticated-orcid":false,"given":"Indu","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Nephrology KMC  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed W","family":"Kashif","sequence":"additional","affiliation":[{"name":"Department of Histopathology PGIMER  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritambhra","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Histopathology PGIMER  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjana","family":"Minz","sequence":"additional","affiliation":[{"name":"Department of Immunopathology PGIMER  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishan L","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Nephrology PGIMER  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harbir S","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Nephrology PGIMER  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.134531"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.127892"},{"key":"e_1_2_6_4_1","first-page":"181","article-title":"Clinical Practice Guideline for Glomerulonephritis","volume":"2","author":"KDIGO","year":"2012","journal-title":"Kidney Int. 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