{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:28:49Z","timestamp":1773872929400,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AG029824"],"award-info":[{"award-number":["U01AG029824"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["334\u2009047, 1\u2009127\u2009060"],"award-info":[{"award-number":["334\u2009047, 1\u2009127\u2009060"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008018","name":"Victorian Cancer Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The prevalence of chronic kidney disease (CKD) in the elderly is controversial because age\u2010related decline in kidney function may not truly reflect underlying kidney disease. We estimate the baseline prevalence and predictors of CKD using the CKD Epidemiology Collaboration (CKD\u2010EPI<jats:sub>eGFR<\/jats:sub>) and Berlin Initiative Study 1 (BIS1<jats:sub>eGFR<\/jats:sub>) eGFR equations in the ASPirin in Reducing Events in the Elderly (ASPREE) trial cohort of healthy older participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GFR was estimated using CKD\u2010EPI and BIS1 equations. CKD was defined as eGFR &lt;60\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> or\u2009\u2265\u200960\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> with urine albumin creatinine ratio (UACR)\u2009\u2265\u20093\u2009mg\/mmol. Logistic regression was used to identify predictors of CKD prevalence defined by each eGFR equation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data for analysis were complete for 17,762 participants. Mean age was 75.1 years (SD 5); 56.4% were female, 76.4% had hypertension, 9% had diabetes mellitus. Mean CKD\u2010EPI<jats:sub>eGFR<\/jats:sub> was 73.0 (SD 14.2), compared with mean BIS1<jats:sub>eGFR<\/jats:sub> of 62.7 (11.4). Median UACR was 0.8 (IQR 0.5, 1.5) mg\/mmol. Prevalence of CKD by CKD\u2010EPI<jats:sub>eGFR<\/jats:sub> was 27% (predominantly due to normoalbuminuric stage 3a CKD), substantially lower than 47.1% by BIS1<jats:sub>eGFR<\/jats:sub>; the difference was predominantly driven by reclassification of individuals from G1 and G2 CKD to stage G3a without albuminuria. Increased prevalence of CKD by either equation was related to older age, hypertension, diabetes, or higher body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prevalence of CKD with CKD\u2010EPI<jats:sub>eGFR<\/jats:sub> was 27%, and doubled using the elderly specific BIS1<jats:sub>eGFR<\/jats:sub>, with most participants reclassified from stage 2 to stage 3a. Increased prevalence of CKD was related older age, hypertension, diabetes, or increased body mass index.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13565","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T05:54:12Z","timestamp":1548050052000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort"],"prefix":"10.1111","volume":"24","author":[{"given":"Kevan R","family":"Polkinghorne","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Nephrology Monash Medical Centre, Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M","family":"Jachno","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B","family":"Wetmore","sequence":"additional","affiliation":[{"name":"Department of Medicine Hennepin Healthcare Systems  Minneapolis Minnesota USA"},{"name":"Hennepin Healthcare Research Institute, Minneapolis  Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn L","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J","family":"McNeil","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R","family":"Nelson","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research University of Tasmania  Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"School of Public Health Curtin University  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Medicine Hennepin Healthcare Systems  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the ASPREE Investigator Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6731"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and Management of Chronic Kidney Disease","volume":"3","author":"KDIGO","year":"2012","journal-title":"Kidney Int. 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