{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:07:47Z","timestamp":1790485667683,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Pattern of kidney diseases varies across geographies due to multiple factors. There is a paucity of information from South Asia due to the absence of nationwide\/regional biopsy registries. This study aimed to delineate the spectrum of renal parenchymal diseases in our region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of kidney biopsies done in our nephrology department between 2006 and 2016 were analysed. Clinico\u2010pathological correlation was done from the available records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 3275 biopsy evaluated, 61.9% were males, and mean age was 33.2\u2009\u00b1\u200914.2\u2009years. 6.2% patients were elderly (age\u2009\u2265\u200960\u2009years). Nephrotic syndrome (60.3%) was the commonest indication for biopsy. On histology, 73.0% patients had primary glomerulonephritis (GN), 15.5% secondary GN, 5.3% tubulo\u2010interstitial and 3.7% vascular disease. Focal segmental glomerulosclerosis (FSGS) was the commonest primary GN accounting for 18.2% of all GNs, followed by minimal change disease (16.8%), membranous nephropathy (MN) (16.0%) and IgA nephropathy (10.4%). Lupus nephritis (10.6%) and amyloidosis (3.7%) were the commonest secondary GN. The commonest cause of nephrotic syndrome was minimal change disease (22.9%), acute nephritic syndrome was lupus nephritis (30.6%), rapidly progressive renal failure was pauci\u2010immune crescentic GN (24.5%). IgA nephropathy was the commonest etiology of asymptomatic urinary abnormalities (26.3%) and gross haematuria (50%). About 60.9% patients of undetermined chronic kidney disease had glomerular diseases, and 13.6% had chronic tubulointerstitial nephritis. Lupus nephritis and acute cortical necrosis were significantly more common in females compared with males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is one of the largest cohorts of kidney biopsies from India, and it delineates the unique features and differences in the pattern of kidney disease in our population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13582","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T03:50:15Z","timestamp":1551757815000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Spectrum of biopsy\u2010proven renal disease in northern India: A single\u2010centre study"],"prefix":"10.1111","volume":"25","author":[{"given":"Parmod","family":"Mittal","sequence":"first","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipankar","family":"Bhowmik","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Dinda","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumita","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-10"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00831.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00833.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi207"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh521"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0430-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0810-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/0971-4065.34863","article-title":"Spectrum of biopsy proven renal disease and changing trends at a tropical tertiary care Centre 1990 \u2013 2001","volume":"13","author":"Balakrishnan N","year":"2003","journal-title":"Indian J Nephrol"},{"key":"e_1_2_11_10_1","first-page":"205","article-title":"Characterization of kidney lesions in Indian adults: Towards a renal biopsy registry","volume":"19","author":"Narasimhan B","year":"2006","journal-title":"J. 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