{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:33:26Z","timestamp":1792802006960,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004776","name":"Faculty of Medicine, Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the levels of intact parathyroid hormone (iPTH) are well\u2010controlled following the Kidney Disease Outcomes Quality Initiative guideline, the incidence of osteoporosis and fracture are still high in haemodialysis (HD) patients. This study was conducted to investigate the correlation between bone turnover markers, bone mineral density (BMD), and bone histomorphometry in HD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two chronic HD patients were enrolled. Serum levels of bone turnover markers were measured. Double tetracycline\u2010labelled iliac crest bone specimens were evaluated using specialized a computer program (Osteomeasure). The types of bone histomorphometry were classified based on turnover, mineralization and volume. BMD and coronary artery calcification were also determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bone histomorphometry revealed osteitis fibrosa (50%), adynamic bone disease (45%) and mixed uremic osteodystrophy (5%). Serum iPTH level predicted high bone turnover with area under the receiver operating characteristic (ROC) of 0.833 (95% CI\u2009=\u20090.665\u20131.000, <jats:italic>P<\/jats:italic> =\u20090.008). Serum TRAP\u20105b also had ROC of 0.733 (95% CI\u2009= 0.517\u20130.950, <jats:italic>P<\/jats:italic> = 0.065). In addition, when using serum iPTH (cut\u2010off 484.50\u2009ng\/mL) or serum TRAP\u20105b (cut\u2010off 1.91\u2009pg.\/mL) to predict high turnover, the sensitivity was 0.917. On the other hand, when both iPTH and TRAP\u20105B were above these cut\u2010off, the specificity was 1.000. Low BMD and severe vascular calcification were commonly identified. However, there were no significant correlations between bone biomarkers and BMD or severe vascular calcification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although iPTH levels were close to the target of Kidney Disease Outcomes Quality Initiative guideline, abnormal bone histomorphometry, BMD, and severe vascular calcification are still common. Bone biopsy is still crucially required as an accurate diagnostic tool in providing optimal guide for the treatment. \u00a9 2019 Asian Pacific Society of Nephrology<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13593","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T09:43:56Z","timestamp":1555148636000},"page":"163-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<b>Bone turnover markers predict type of bone histomorphometry and bone mineral density in Asian chronic haemodialysis patients<\/b>"],"prefix":"10.1111","volume":"25","author":[{"given":"Suthanit","family":"Laowalert","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanatorn","family":"Khotavivattana","sequence":"additional","affiliation":[{"name":"Center of Excellence in Natural Products Chemistry, Department of Chemistry Faculty of Science, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita","family":"Wattanachanya","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pobe","family":"Luangjarmekorn","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwasin","family":"Udomkarnjananun","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisut","family":"Katavetin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Eiam\u2010Ong","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kearkiat","family":"Praditpornsilpa","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paweena","family":"Susantitaphong","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.06.028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330307"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000414"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001754"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.020"},{"key":"e_1_2_7_7_1","first-page":"S1","article-title":"Improving global outcomes CKDMBDWG. 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