{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:50:53Z","timestamp":1780555853185,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003766","name":"Ministerul Educatiei Nationale","doi-asserted-by":"publisher","award":["NRF\u20102017R1D1A1B03031642"],"award-info":[{"award-number":["NRF\u20102017R1D1A1B03031642"]}],"id":[{"id":"10.13039\/501100003766","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>In addition to immunological complications, non\u2010immunological events should be considered following kidney transplantation. Among them, diarrhoea is the most common gastrointestinal complication, but its effect on transplant outcomes remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study enrolled patients who underwent kidney transplantation between May 1993 and December 2017. Patients with diarrhoea as the chief complaint at admission were defined as the diarrhoea group. Transplant outcomes were compared between the diarrhoea and non\u2010diarrhoea groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among a total of 1704 kidney recipients, severe diarrhoea that required hospitalization was identified in 84 (4.9%) patients. Patients with diarrhoea showed higher risks of graft failure (adjusted hazard ratio, 4.77 (2.98\u20137.64)) and all\u2010cause mortality (adjusted hazard ratio, 7.17 (4.09\u201312.58)) than did patients without diarrhoea. The risk of <jats:italic>de novo<\/jats:italic> donor\u2010specific antibody was also elevated in the diarrhoea group, although there was no change in the risk of biopsy\u2010proven rejection. In subgroup analysis, the aetiology of diarrhoea, as well as a change in immunosuppressant following diarrhoea, showed no significant differences in graft survival. However, incomplete recovery from concurrent acute kidney injury was significantly associated with graft loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diarrhoea is related to poor graft and patients\u2019 outcomes in kidney recipients. An effort to recover from concurrent acute kidney injury is important for improved graft survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13599","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T07:33:43Z","timestamp":1557732823000},"page":"255-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of severe diarrhoea on kidney transplant outcomes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-2229","authenticated-orcid":false,"given":"Ji Eun","family":"Kim","sequence":"first","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongwon","family":"Ha","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Surgery Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Seok","family":"Han","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul South Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"The UNOS Renal Transplant Registry: Review of the last decade","author":"Andre M","year":"2014","journal-title":"Clin. Transpl."},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Kidney transplantation in the US: An analysis of the OPTN\/UNOS registry","author":"Freitas MC","year":"2011","journal-title":"Clin. Transpl."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V113582"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.12.043"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2005.00134.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92534-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199908150-00011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200107150-00014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200003150-00035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000128637.16601.48"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2002.01129.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251923.14697.f5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000284983.89207.1a"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2007.00237.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000444"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.11.013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.tb00394.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.02.349"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu880"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000172"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199806150-00007"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014040326"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01312.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110041"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-017-0989-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00832"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq025"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01320.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.10.019"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.12.019"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.13599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.13599","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T15:17:10Z","timestamp":1694099830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,30]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/nep.13599"],"URL":"https:\/\/doi.org\/10.1111\/nep.13599","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,30]]},"assertion":[{"value":"2019-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}